Uricosuric
Uricosuric are medications that the renal excretion of uric acid increase.
Active ingredients
Probenecid , benzbromarone or Isobromindion are uricosuric. Medicines containing the active ingredient sulfinpyrazone are not commercially available.
Mechanism of action
Uricosurics inhibit tubular uric acid reabsorption on the brush border membrane of the kidney tubules . The point of attack of the uricosurics is the uric acid anion exchange protein URAT1 .
Side effects
Side effects can be a crystallization of uric acid in the urine , an acute attack of gout at the start of therapy or gastrointestinal complaints.
indication
The medication intake is indicated for hyperuricemia without kidney involvement.
Contraindications
The drug is not allowed to be taken with disorders of kidney function . You are strongly warned against using it for kidney stones ( cave ).
