Benzbromaron

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Structural formula
Benzbromaron
General
Non-proprietary name Benzbromaron
other names

(2-Ethyl-3-benzofuranyl) - (3,5-dibromo-4-hydroxyphenyl) ketone ( IUPAC )

Molecular formula C 17 H 12 Br 2 O 3
Brief description

white to almost white, crystalline powder

External identifiers / databases
CAS number 3562-84-3
EC number 222-630-7
ECHA InfoCard 100.020.573
PubChem 2333
Wikidata Q410435
Drug information
ATC code

M04 AB03

Drug class

Urikosurika

properties
Molar mass 424.09 g · mol -1
Physical state

firmly

Melting point

151 ° C

solubility

practically insoluble in water, slightly soluble in acetone and dichloromethane , slightly soluble in ethanol

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
06 - Toxic or very toxic

danger

H and P phrases H: 301
P: 301 + 310
Toxicological data

248 mg kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Benzbromaron is a drug used to treat high uric acid levels ( hyperuricemia ), the symptom-free intervals of gout and chronic gout .

Benzbromaron inhibits the tubular reabsorption of uric acid . This is increasingly excreted ( uricosuric effect ), whereupon the uric acid concentration in the blood drops. Benzbromaron is also used in combination with allopurinol , which, however, does not have any clear advantages over monotherapy, as the active metabolite of allopurinol, oxipurinol, is also increasingly excreted.

As side effects of uricosuric drugs, insoluble uric acid salts can form in the kidneys and urinary tract .

To support the long-term therapy, a low-purine diet and weight reduction as well as the avoidance of alcohol are recommended .

Individual evidence

  1. ↑ a b data sheet BENZBROMARONE CRS (PDF) at EDQM , accessed on July 27, 2008.
  2. ↑ a b Entry on benzbromarone in the ChemIDplus database of the United States National Library of Medicine (NLM) .
  3. ↑ a b data sheet Benzbromarone from Sigma-Aldrich , accessed on November 7, 2016 ( PDF ).

Trade names

Monopreparations

Generic (D)

Combination preparations

Allobenz (A), Allopurinol comp. (D), Gichtex plus (A)