Sulfinpyrazone

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Structural formula
Structural formula of sulfinpyrazone
Structural formula without stereochemistry - stereocenter on the sulfur atom of the S = O group
General
Surname Sulfinpyrazone
other names
  • (±) -1,2-Diphenyl-4- [2- (phenylsulfinyl) ethyl] pyrazolidine-3,5-dione
  • ( RS ) -1,2-Diphenyl-4- [2- (phenylsulfinyl) ethyl] pyrazolidine-3,5-dione
  • rac -1,2-diphenyl-4- [2- (phenylsulfinyl) ethyl] pyrazolidine-3,5-dione
Molecular formula C 23 H 20 N 2 O 3 S
Brief description

White dust

External identifiers / databases
CAS number 57-96-5
EC number 200-357-4
ECHA InfoCard 100,000,325
PubChem 5342
ChemSpider 5149
DrugBank DB01138
Wikidata Q3790542
Drug information
ATC code

M04 AB02

properties
Molar mass 404.48 g mol −1
Physical state

firmly

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 302
P: no P-phrases
Toxicological data

358 mg kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sulfinpyrazone is a 1: 1 mixture of two stereoisomeric chemical compounds from the group of pyrazolidines .

Extraction and presentation

Sulfinpyrazone can be obtained by reacting hydrazobenzene with diethyl 2- (2-phenylmercaptoethyl) malonate.

Sulfinpyrazone synthesis

properties

Sulfinpyrazone is a white odorless powder that is sparingly soluble in water.

use

Sulfinpyrazone is used in medicine as a platelet aggregation inhibitor from the group of uricosuric drugs . It is used against gout.

Individual evidence

  1. ↑ a b c d e f data sheet Sulfinpyrazon, analytical standard, for drug analysis at Sigma-Aldrich , accessed on November 4, 2016 ( PDF ).
  2. ↑ a b c Margitta Albinus: Hager's Handbook of Pharmaceutical Practice: Substances E - O. Springer DE, 1993, ISBN 3-540-52688-9 , p. 731–733 ( limited preview in Google Book search).
  3. ↑ Entry on sulfinpyrazone in Pharmawiki , accessed on January 28, 2017.