VGF (neuropeptide)
| Neurosecretory protein VGF | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 593 amino acids; 65 kDa | |
| Identifier | ||
| Gene name | VGF | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Euarchontoglires | |
| Orthologue | ||
| human | mouse | |
| Entrez | 7425 | 381677 |
| Ensemble | ENSG00000128564 | ENSMUSG00000037428 |
| UniProt | O15240 | |
| Refseq (mRNA) | NM_003378 | NM_001039385 |
| Refseq (protein) | NP_003369 | NP_001034474 |
| Gene locus | Chr 7: 100.59 - 100.6 Mb | Chr 5: 137.51 - 137.51 Mb |
| PubMed search | 7425 |
381677
|
VGF is a peptide , which is also known as "VGF nerve growth factor inducible protein", "neuroendocrine specific protein" or "VGF protein" and was discovered in 1985. It consists of 593 amino acids and is controlled by the tissue hormone NGF . The molar mass is 65 kDa . VGF and its fragments play a role in energy balance , food intake and mood. VGF is released by neurons in the central and peripheral nervous system , as well as cells in the adrenal gland and beta cells in the endocrine part of the pancreas .
Literature and references
- ↑ Levi A, JD Eldridge, BM Paterson, Science 229: 393-395, 1985
- ↑ UniProt entry
- ↑ AN van den Pol, C Decavel, A Levi and B Paterson, Hypothalamic expression of a novel gene product, VGF: immunocytochemical analysis, Journal of Neuroscience, Vol 9, 4122-4137
- ↑ WIPO: Method for the detection of chronic dementia diseases, associated peptides and detection reagents
- van den Pol AN et al .: VGF expression in the brain, J Comp Neurol. 1994 Sep 15; 347 (3): 455-69
- Smita Thakker-Varia et al .: The Neuropeptide VGF Produces Antidepressant-Like Behavioral Effects and Enhances Proliferation in the Hippocampus, Journal of Neuroscience, November 7, 2007, 27 (45): 12156-12167
- Angelo L. Garcia: A Prohormone Convertase Cleavage Site within a Predicted alpha-Helix Mediates Sorting of the Neuronal and Endocrine Polypeptide VGF into the Regulated Secretory Pathway, J. Biol. Chem., Vol. 280, Issue 50, 41595-41608, December 16, 2005. doi : 10.1074 / jbc.M509122200
- Hahm S et al .: VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J Neurosci 2002, 22: 6929-6938.