Valepotriate
Valepotriate is the name for a group of herbal ingredients found in the valerian plants, real medicinal valerian ( Valeriana officinalis ), Valeriana wallichii , Valeriana mexicana and red spurflower ( Centranthus ruber ). The designation goes to " Val eriana- Epo xy Tri back ester".
Chemical structure
The valepotriates are iridoids whose hydroxyl groups are esterified with isovaleric acid and acetic acid and have an epoxy ring.
| Surname | structure | R 1 | R 2 | R 3 | PubChem |
|---|---|---|---|---|---|
| Valtrat |  |
Acetyl | Isovaleryl | Isovaleryl | 442436 |
| Isovaltrate | Isovaleryl | Acetyl | Isovaleryl | 92275 | |
| Dihydrovaltrate |  |
Isovaleryl | Acetyl | Isovaleryl | 65689 |
| Homodihydrovaltrate | Isovaleryl | Acetyl | 3-methylvaleryl |
Occurrence
Valtrat is a colorless oil that is also found in the kesso root and is optically active .
Biological effects
The valepotriates are given an equilibrating , i. H. Attributed to sedating when aroused and activating when tired. However, they are not found in valerian tea and tincture .
In vitro , valepotriates and their metabolites show alkylating , cytotoxic and mutagenic effects.
Individual evidence
- ↑ a b Entry on Valepotriate. In: Römpp Online . Georg Thieme Verlag, accessed on June 13, 2014.