Virodhamin

Structural formula
General
Surname	Virodhamin
other names	O -Arachidonylethanolamide
Molecular formula	C 22 H 37 NO 2
Brief description	viscous solid (hydrochloride)
External identifiers / databases
ECHA InfoCard	100.158.921
PubChem	5712057
Wikidata	Q4463
Drug information
Drug class	Endocannabinoid
Mechanism of action	Cannabinoid Receptor - CB 1 - Antagonist
properties
Molar mass	347.53 g · mol -1
Physical state	firmly
solubility	Hydrochloride soluble in DMF , DMSO and ethanol (≥20 g l −1 )
safety instructions
GHS labeling of hazardous substances Hydrochloride; Caution
H and P phrases	H: 315-319-335
	P: 261-305 + 351 + 338
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Virodhamin , also known as O -arachidonylethanolamide , is an eicosanoid , neurotransmitter and endocannabinoid , which acts as a cannabinoid receptor - CB ₁ - antagonist and CB ₂ - agonist .

effect

Virodhamin lowers the body temperature of mice.

history

Since O -Arachidonylethanolamide has the opposite effect of the unsaturated fatty acid, anandamide , it was named after the Sanskrit word virodha , which means opposite .

Individual evidence

↑ ^a ^b ^c ^d ^e data sheet Virodhamine hydrochloride,> 90% (GC), oil from Sigma-Aldrich , accessed on December 28, 2015 ( PDF ).
↑ ^a ^b Porter AC: Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor . In: J. Pharmacol. Exp. Ther. . 301, No. 3, 2002, pp. 1020-4. doi : 10.1124 / jpet.301.3.1020 . PMID 12023533 .

[Sigma-1] ↑ ^a ^b ^c ^d ^e data sheet Virodhamine hydrochloride,> 90% (GC), oil from Sigma-Aldrich , accessed on December 28, 2015 ( PDF ).

[pmid12023533-2] Porter AC: Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor . In: J. Pharmacol. Exp. Ther. . 301, No. 3, 2002, pp. 1020-4. doi : 10.1124 / jpet.301.3.1020 . PMID 12023533 .