Virodhamin
Structural formula | ||||||||||
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General | ||||||||||
Surname | Virodhamin | |||||||||
other names |
O -Arachidonylethanolamide |
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Molecular formula | C 22 H 37 NO 2 | |||||||||
Brief description |
viscous solid (hydrochloride) |
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Drug information | ||||||||||
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Mechanism of action | ||||||||||
properties | ||||||||||
Molar mass | 347.53 g · mol -1 | |||||||||
Physical state |
firmly |
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solubility |
Hydrochloride soluble in DMF , DMSO and ethanol (≥20 g l −1 ) |
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safety instructions | ||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Virodhamin , also known as O -arachidonylethanolamide , is an eicosanoid , neurotransmitter and endocannabinoid , which acts as a cannabinoid receptor - CB 1 - antagonist and CB 2 - agonist .
effect
Virodhamin lowers the body temperature of mice.
history
Since O -Arachidonylethanolamide has the opposite effect of the unsaturated fatty acid, anandamide , it was named after the Sanskrit word virodha , which means opposite .
Individual evidence
- ↑ a b c d e data sheet Virodhamine hydrochloride,> 90% (GC), oil from Sigma-Aldrich , accessed on December 28, 2015 ( PDF ).
- ↑ a b Porter AC: Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor . In: J. Pharmacol. Exp. Ther. . 301, No. 3, 2002, pp. 1020-4. doi : 10.1124 / jpet.301.3.1020 . PMID 12023533 .