Cytoprotection

from Wikipedia, the free encyclopedia

As cytoprotection , and cell protection called, refers to a supportive therapy strategy with which the healthy body cells against toxic to be protected effects.

In oncology , cytoprotectors are supposed to protect healthy cells from the negative effects of radiation or chemotherapy without negatively affecting the antitumor effectiveness of the therapy.

Examples of approved cytoprotectors are amifostine , mesna and dexrazoxane .

In the anatomy of the gastrointestinal tract , for example, the glandular mucous membrane of the stomach , the pars glandularis , is referred to as cytoprotection. Here the cardia and pyloric glands ( glandulae cardiacae et pyloricae ) form a slimy secretion ("mucus"), which covers the stomach wall as a protective layer and protects it from self-digestion .

See also

literature

  • Guidelines on cytoprotection / mucositis / skin toxicity of the Working Group Supportive Measures in Oncology, Rehabilitation and Social Medicine of the German Cancer Society of December 30, 2008
  • WP Hogle: Cytoprotective agents used in the treatment of patients with cancer. In: Seminars in oncology nursing Volume 23, Number 3, August 2007, pp. 213-224, ISSN  0749-2081 . doi : 10.1016 / j.soncn.2007.05.006 . PMID 17693348 . (Review).
  • K. Bisht, KH Wagner, AC Bulmer: Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds. In: Toxicology Volume 278, Number 1, November 2010, pp. 88-100. PMID 19903510 . (Review).
  • LG Korkina, C. De Luca, VA Kostyuk, S. Pastore: Plant polyphenols and tumors: from mechanisms to therapies, prevention, and protection against toxicity of anti-cancer treatments. In: Current Medicinal Chemistry Volume 16, Number 30, 2009, pp. 3943-3965, ISSN  1875-533X . PMID 19747130 . (Review).
  • JL Wallace: Prostaglandins, NSAIDs, and cytoprotection. In: Gastroenterology clinics of North America Volume 21, Number 3, September 1992, pp. 631-641, ISSN  0889-8553 . PMID 1516961 . (Review).

Individual evidence

  1. ↑ a b J. Büntzel, F. Bruns, D. Lüftner, D. Pollmann, S. Schildhauer: Protective drugs (organ protectors). In: H. Link, C. Bokemeyer, P. Feyer (eds.): Supportive therapy for malignant diseases. Deutscher Ärzteverlag, 2006, ISBN 3-769-10466-8 , pp. 99–114. limited preview in Google Book search