Tissue factor pathway inhibitor: Difference between revisions
infobox |
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* [[hemostasis]] |
* [[hemostasis]] |
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==External |
==External links== |
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* {{OMIM|152310}} (''TFPI1''), {{OMIM|600033}} (''TFPI2'') |
* {{OMIM|152310}} (''TFPI1''), {{OMIM|600033}} (''TFPI2'') |
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{{Coagulation}} |
{{Coagulation}} |
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[[Category:Coagulation system]] |
[[Category:Coagulation system]] |
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Revision as of 08:49, 16 November 2007
| tissue factor pathway inhibitor | |||||||
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| Identifiers | |||||||
| Symbol | TFPI | ||||||
| Alt. symbols | LACI | ||||||
| NCBI gene | 7035 | ||||||
| HGNC | 11760 | ||||||
| OMIM | 152310 | ||||||
| RefSeq | NM_001032281 | ||||||
| UniProt | P10646 | ||||||
| Other data | |||||||
| Locus | Chr. 2 q31-q32.1 | ||||||
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Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-TF complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5nM.
Genetics
The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70kb. The gene has not been completely sequenced yet. A similar gene, termed TFPI2, has been identified on chromosome 7q22; in addition to TFPI activity, its product also has retinal pigment epithelial cell growth-promoting properties.
Protein structure
TFPI has a relative molecular mass of 34000 to 40000 depending on the degree of proteolysis of the C-terminal region.
See also
External links
- Online Mendelian Inheritance in Man (OMIM): 152310 (TFPI1), Online Mendelian Inheritance in Man (OMIM): 600033 (TFPI2)
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