Protein Z

Protein Z
	Existing structural data: 1LP1
Properties of human protein
Mass / length primary structure	360 amino acids
Cofactor	Vitamin K
Identifier
Gene name	PROC
External IDs	OMIM : 176895 ; UniProt : P22891 ;
Occurrence
Parent taxon	Creature

Protein Z is a vitamin K -dependent glycoprotein in the blood plasma , which is formed in the liver and is involved in blood clotting .

Protein Z has a molar mass of 62 kDa and consists of 360 amino acids . It was detected in cattle in 1977 and in humans in 1984. Protein Z is involved in coagulation by supporting the accumulation of thrombin on endothelial phospholipid surfaces and by using a specific protease inhibitor to inhibit the procoagulant activity of factor Xa . Protein Z itself has no catalytic function.

A decreased level of protein Z has been linked to thrombosis and miscarriage .

Individual evidence

↑ CV Prowse, MP Esnouf: The isolation of a new warfarin-sensitive protein from bovine plasma . In: Biochem. Soc. Trans. . 5, No. 1, 1977, pp. 255-256. PMID 892175 .
↑ GJ Broze, Miletich JP: Human Protein Z . In: Journal of Clinical Investigation . tape 73 , no. 4 , April 1, 1984, pp. 933-938 , doi : 10.1172 / JCI111317 (English).
↑ J. Barth, K. Röhl, D. Jäger: Protein Z deficiency as a rare cause of unclear perioperative bleeding . In: AINS . tape 38 , no. 9 , September 2003, p. 605-608 , doi : 10.1055 / s-2003-41858 .
↑ Antje Butschkau, Nana-Maria Wagner, Berit Genz, Brigitte Vollmar, Ingo Ahrens: Protein Z Exerts Pro-Angiogenic Effects and Upregulates CXCR4 . In: PLoS ONE . tape 9 , no. 12 , December 4, 2014, p. e113554 , doi : 10.1371 / journal.pone.0113554 (English).
↑ F. Sofi, F. Cesari, R. Abbate, GF Gensini, GJ Broze, S. Fedi: A meta-analysis of potential risks of low levels of protein Z for diseases related to vascular thrombosis . In: Thrombosis and Haemostasis . tape 103 , no. 4 , 2010, p. 749-756 , doi : 10.1160 / TH09-09-0645 (English).
↑ B. Hoppe, A. Salama, H. Kiesewetter, Th. Dörner: Protein-Z-Levels and Protein-Z-Antibodies in case of tendency to abort: current perspectives . In: Vascular Care . tape 7 , no. 32 , February 2004 ( vascularcare.de [PDF]).

[1] CV Prowse, MP Esnouf: The isolation of a new warfarin-sensitive protein from bovine plasma . In: Biochem. Soc. Trans. . 5, No. 1, 1977, pp. 255-256. PMID 892175 .

[broze-2] GJ Broze, Miletich JP: Human Protein Z . In: Journal of Clinical Investigation . tape 73 , no. 4 , April 1, 1984, pp. 933-938 , doi : 10.1172 / JCI111317 (English).

[ains-3] J. Barth, K. Röhl, D. Jäger: Protein Z deficiency as a rare cause of unclear perioperative bleeding . In: AINS . tape 38 , no. 9 , September 2003, p. 605-608 , doi : 10.1055 / s-2003-41858 .

[pone-4] Antje Butschkau, Nana-Maria Wagner, Berit Genz, Brigitte Vollmar, Ingo Ahrens: Protein Z Exerts Pro-Angiogenic Effects and Upregulates CXCR4 . In: PLoS ONE . tape 9 , no. 12 , December 4, 2014, p. e113554 , doi : 10.1371 / journal.pone.0113554 (English).

[sofi-5] F. Sofi, F. Cesari, R. Abbate, GF Gensini, GJ Broze, S. Fedi: A meta-analysis of potential risks of low levels of protein Z for diseases related to vascular thrombosis . In: Thrombosis and Haemostasis . tape 103 , no. 4 , 2010, p. 749-756 , doi : 10.1160 / TH09-09-0645 (English).

[hoppe-6] B. Hoppe, A. Salama, H. Kiesewetter, Th. Dörner: Protein-Z-Levels and Protein-Z-Antibodies in case of tendency to abort: current perspectives . In: Vascular Care . tape 7 , no. 32 , February 2004 ( vascularcare.de [PDF]).