Solute carrier organic anion transporter family member 1B3: Difference between revisions
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{{PBB|geneid=28234}} |
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'''Solute carrier organic anion transporter family member 1B3''' is a [[ |
'''Solute carrier organic anion transporter family member 1B3''' is a [[gene]] that encodes a 12-transmembrane domain influx transporter, ''OATP1B3'' [[protein]].<ref name="entrez">{{cite web | title = Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28234| accessdate = }}</ref> Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein. |
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==OATP1B3 in Cancer== |
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OATP1B3 has also been indentified as a testosterone transporter abberantly expressed in prostate cancer and implicated in prostate cancer progression.<ref>{{cite web | title = Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer. |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/18519758| accessdate = }}</ref>, <ref>{{cite web | title = A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer. |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/18537956| accessdate = }}</ref>. |
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==Substrates== |
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Amanitin <ref>{{cite web | title = Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/18668430| accessdate = }}</ref> <br> |
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Atrasentan <br> |
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Bilirubin <br> |
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Bosentan <br> |
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BQ-123 <br> |
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Bromosulfophthalein (BSP) <br> |
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CDCA-NBD <br> |
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Cholate (CA) <br> |
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Cholecystokinin octapeptide (CCK-8) <br> |
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Dehydroepiandroserone-3-sulfate (DHEAS) <br> |
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Deltorphin II <br> |
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Demethylphalloin <br> |
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Digoxin <br> |
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Docetaxel <br> |
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[D-penicillamine2,5]enkephalin (DPDPE) <br> |
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Enalapril <br> |
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Oestradiol-17β-glucuronide 5–25 <br> |
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Oestrone-3-sulfate <br> |
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Fexofenadine <br> |
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Fluvastatin <br> |
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Fluo-3 <br> |
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Glutathione (GSH) <br> |
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Glycocholate (GCA) <br> |
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Glycoursodeoxycholate (GUDCA) <br> |
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Irinotecan <br> |
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Leukotriene C4 (LTC4) <br> |
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Methotrexate <br> |
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Microcystin <br> |
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Monoglyucuronosyl <br> |
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Olmesartan<br> |
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Ouabain <br> |
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Paclitaxel<br> |
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Phalloidin <br> |
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Pitavastatin <br> |
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Rifampicin <br> |
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Ro 48-5033 (Bosentan metabolite) <br> |
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Rosuvastatin <br> |
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SN-38<br> |
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Taurocholate (TCA) <br> |
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Taurochenodeoxycholate (TCDCA) <br> |
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Taurodeoxycholate (TDCA) <br> |
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Tauroursodeoxycholate (TUDCA) <br> |
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Telmisartan <br> |
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Testosterone<br> |
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Thyroxine (T4) <br> |
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TR-14035<br> |
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Triiodothyronine (T3)<br> |
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Valsartan |
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==See also== |
==See also== |
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Revision as of 16:56, 31 January 2011
Template:PBB Solute carrier organic anion transporter family member 1B3 is a gene that encodes a 12-transmembrane domain influx transporter, OATP1B3 protein.[1] Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.
OATP1B3 in Cancer
OATP1B3 has also been indentified as a testosterone transporter abberantly expressed in prostate cancer and implicated in prostate cancer progression.[2], [3].
Substrates
Amanitin [4]
Atrasentan
Bilirubin
Bosentan
BQ-123
Bromosulfophthalein (BSP)
CDCA-NBD
Cholate (CA)
Cholecystokinin octapeptide (CCK-8)
Dehydroepiandroserone-3-sulfate (DHEAS)
Deltorphin II
Demethylphalloin
Digoxin
Docetaxel
[D-penicillamine2,5]enkephalin (DPDPE)
Enalapril
Oestradiol-17β-glucuronide 5–25
Oestrone-3-sulfate
Fexofenadine
Fluvastatin
Fluo-3
Glutathione (GSH)
Glycocholate (GCA)
Glycoursodeoxycholate (GUDCA)
Irinotecan
Leukotriene C4 (LTC4)
Methotrexate
Microcystin
Monoglyucuronosyl
Olmesartan
Ouabain
Paclitaxel
Phalloidin
Pitavastatin
Rifampicin
Ro 48-5033 (Bosentan metabolite)
Rosuvastatin
SN-38
Taurocholate (TCA)
Taurochenodeoxycholate (TCDCA)
Taurodeoxycholate (TDCA)
Tauroursodeoxycholate (TUDCA)
Telmisartan
Testosterone
Thyroxine (T4)
TR-14035
Triiodothyronine (T3)
Valsartan
See also
References
- ^ "Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3".
- ^ "Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer".
- ^ "A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer".
- ^ "Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family".
Further reading
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