Sodium-dependent neutral amino acid transporter B(0)AT2: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
m minuses; chemical superscripts; titles end without period; stub after categories; sp. Sagné, Bröer; -et al+actual names
Monkbot (talk | contribs)
Bots
3,119,769 edits
Line 4: Line 4:
== Function ==
== Function ==


SLC6A15 shows structural characteristics of an Na<sup>+</sup> and Cl<sup>−</sup>-dependent [[neurotransmitter]] transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-[[glycosylation]] sites.<ref name="pmid11112352">{{cite journal | author = Farmer MK, Robbins MJ, Medhurst AD, Campbell DA, Ellington K, Duckworth M, Brown AM, Middlemiss DN, Price GW, Pangalos MN | title = Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na<sup>+</sup>/Cl<sup>−</sup> -dependent neurotransmitter transporter gene family | journal = Genomics | volume = 70 | issue = 2 | pages = 241–52 | year = 2000 | month = December | pmid = 11112352 | doi = 10.1006/geno.2000.6387 }}</ref>
SLC6A15 shows structural characteristics of an Na<sup>+</sup> and Cl<sup>−</sup>-dependent [[neurotransmitter]] transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-[[glycosylation]] sites.<ref name="pmid11112352">{{cite journal | author = Farmer MK, Robbins MJ, Medhurst AD, Campbell DA, Ellington K, Duckworth M, Brown AM, Middlemiss DN, Price GW, Pangalos MN | title = Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na<sup>+</sup>/Cl<sup>−</sup> -dependent neurotransmitter transporter gene family | journal = Genomics | volume = 70 | issue = 2 | pages = 241–52 |date=December 2000 | pmid = 11112352 | doi = 10.1006/geno.2000.6387 }}</ref>


==Clinical relevance==
==Clinical relevance==
Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.<ref name="pmid21521612">{{cite journal | author = Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB | title = The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression | journal = Neuron | volume = 70 | issue = 2 | pages = 252–65 | year = 2011 | month = April | pmid = 21521612 | doi = 10.1016/j.neuron.2011.04.005 }}</ref>
Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.<ref name="pmid21521612">{{cite journal | author = Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB | title = The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression | journal = Neuron | volume = 70 | issue = 2 | pages = 252–65 |date=April 2011 | pmid = 21521612 | doi = 10.1016/j.neuron.2011.04.005 }}</ref>


==References==
==References==

Revision as of 03:31, 30 January 2014

Template:PBB Solute carrier family 6 member 15 (SLC6A15) also known as the sodium-dependent neutral amino acid transporter B(0)AT2 (B0AT2)' is a protein that in humans is encoded by the SLC6A15 gene.[1]

Function

SLC6A15 shows structural characteristics of an Na+ and Cl−-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[2]

Clinical relevance

Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.[3]

References

  1. ^ "Entrez Gene: solute carrier family 6 (neutral amino acid transporter)".
  2. ^ Farmer MK, Robbins MJ, Medhurst AD, Campbell DA, Ellington K, Duckworth M, Brown AM, Middlemiss DN, Price GW, Pangalos MN (December 2000). "Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl− -dependent neurotransmitter transporter gene family". Genomics. 70 (2): 241–52. doi:10.1006/geno.2000.6387. PMID 11112352.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB (April 2011). "The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression". Neuron. 70 (2): 252–65. doi:10.1016/j.neuron.2011.04.005. PMID 21521612.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Further reading

  • Bröer, Angelika; Tietze, Nadine; Kowalczuk, Sonja; Chubb, Sarah; Mumzinger, Michael; BAK, Lasse K; Bröer, Stefan (2006). "The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2)". Biochem. J. 393 (Pt 1): 421–30. doi:10.1042/BJ20051273. PMID 16185194.
  • Zaia KA, Reimer RJ (2009). "Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport". J. Biol. Chem. 284 (13): 8439–48. doi:10.1074/jbc.M806407200. PMID 19147495.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
  • Takanaga H, Mackenzie B, Peng JB, Hediger MA (2005). "Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain". Biochem. Biophys. Res. Commun. 337 (3): 892–900. doi:10.1016/j.bbrc.2005.09.128. PMID 16226721.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Masson, J; Sagné, C; Hamon, M; El Mestikawy, S (1999). "Neurotransmitter transporters in the central nervous system". Pharmacol. Rev. 51 (3): 439–64. PMID 10471414.

References



Stub icon

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Sodium-dependent_neutral_amino_acid_transporter_B(0)AT2&oldid=593060499"