Antiprogestogen: Difference between revisions
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An '''antiprogestogen''', also called an '''antiprogesterone agent''', or in the case of a [[Organic compound#Synthetic compounds|synthetic]] compound, an '''antiprogestin''', is a type of [[hormone antagonist]] |
An '''antiprogestogen''', also called an '''antiprogesterone agent''', or in the case of a [[Organic compound#Synthetic compounds|synthetic]] compound, an '''antiprogestin''', is a type of [[hormone antagonist]] which antagonizes or suppresses the action of [[progesterone]] in the body, a [[sex hormone]] that plays a [[role]] in the [[menstrual cycle]] and [[pregnancy]]. Antiprogestogens may stop some [[cancer cells]] from [[Cell growth|growing]] and they are being studied in the treatment of [[breast cancer]]. They are also used as [[abortifacient]]s. |
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Examples of antiprogestogens include [[mifepristone]] (weak [[partial agonist]]) and [[aglepristone]] ([[silent antagonist|full antagonist]]).<ref name="Spitz-2006">{{Cite journal | last1 = Spitz | first1 = IM. | title = Progesterone receptor antagonists. | journal = Curr Opin Investig Drugs | volume = 7 | issue = 10 | pages = 882–90 |date=Oct 2006 | doi = | PMID = 17086932 }}</ref><ref name="Tang-2006">{{Cite journal | last1 = Tang | first1 = OS. | last2 = Ho | first2 = PC. | title = Clinical applications of mifepristone. | journal = Gynecol Endocrinol | volume = 22 | issue = 12 | pages = 655–9 |date=Dec 2006 | doi = 10.1080/09513590601005946 | PMID = 17162706 }}</ref> |
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Medical termination of pregnancy: mifepristone |
Medical termination of pregnancy: mifepristone combined with a [[prostaglandin]] (e.g., [[gemeprost]]). |
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==See also== |
==See also== |
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* [[Progesterone]] |
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* [[Progestogen]] |
* [[Progestogen]] |
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* [[Progestin]] |
* [[Progestin]] |
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* [[Selective progesterone receptor modulator |
* [[Selective progesterone receptor modulator]] |
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* [[Antiestrogen]] |
* [[Antiestrogen]] |
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* [[Antiandrogen]] |
* [[Antiandrogen]] |
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==References== |
==References== |
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{{Reflist}} |
{{Reflist|2}} |
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==External links== |
==External links== |
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Revision as of 22:31, 3 January 2015
An antiprogestogen, also called an antiprogesterone agent, or in the case of a synthetic compound, an antiprogestin, is a type of hormone antagonist which antagonizes or suppresses the action of progesterone in the body, a sex hormone that plays a role in the menstrual cycle and pregnancy. Antiprogestogens may stop some cancer cells from growing and they are being studied in the treatment of breast cancer. They are also used as abortifacients.
Examples of antiprogestogens include mifepristone (weak partial agonist) and aglepristone (full antagonist).[1][2]
Medical termination of pregnancy: mifepristone combined with a prostaglandin (e.g., gemeprost).
See also
References
External links
- Antiprogestin entry in the public domain NCI Dictionary of Cancer Terms
This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.
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