Apigenin
Structural formula | ||||||||||||||||||||||
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General | ||||||||||||||||||||||
Surname | Apigenin | |||||||||||||||||||||
other names | ||||||||||||||||||||||
Molecular formula | C 15 H 10 O 5 | |||||||||||||||||||||
Brief description |
yellow needles |
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properties | ||||||||||||||||||||||
Molar mass | 270.24 g mol −1 | |||||||||||||||||||||
Physical state |
firmly |
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Melting point |
352 ° C |
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solubility |
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safety instructions | ||||||||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Apigenin is a light yellow plant pigment from the group of flavones .
Occurrence
Apigenin is including in the celery , the chamomile in dahlias and henna before.
effect
Although apigenin has cytostatic activity in some cell cultures of malignant tumor cells in the laboratory by stopping the cell cycle in the G 2 / M phase ( mitotic phase ), there is no study on the effect on tumors outside the laboratory no approval for the treatment of cancer. Apigenin is also an inhibitor of estrogen - synthetase of the people, even for this but there is no clinical trial and not scientifically based treatment recommendations.
In animal models, apigenin has a calming and anxiety-relieving effect because it interacts with the benzodiazepine receptor in the brain, but there are also no clinical studies on its effects in humans.
Related links
The glucoside of apigenin is apiin .
Individual evidence
- ↑ Entry on APIGENIN in the CosIng database of the EU Commission, accessed on March 23, 2020.
- ↑ a b c Entry on apigenin. In: Römpp Online . Georg Thieme Verlag, accessed on September 3, 2019.
- ↑ a b c data sheet apigenin (PDF) from Carl Roth , accessed on September 3, 2019.
- ↑ Apigenin data sheet from Sigma-Aldrich , accessed on September 3, 2019 ( PDF ).
- ↑ RR Ruela-de-Sousa, GM Fuhler and a .: Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy. In: Cell death & disease. Volume 1, 2010, p. E19, doi : 10.1038 / cddis.2009.18 . PMID 21364620 . PMC 3032507 (free full text).
- ↑ H. Viola, C. Wasowski, M. Levi de Stein, C. Wolfman, R. Silveira, F. Dajas, JH Medina, AC Paladini: Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. In: Planta medica. Volume 61, Number 3, June 1995, pp. 213-216, doi : 10.1055 / s-2006-958058 , PMID 7617761 .