Multidrug and toxin extrusion protein 1
Template:PBB Solute carrier family 47, member 1, also known as SLC47A1, is a protein which in humans is encoded by the SLC47A1 gene.[1][2] SLC47A1 belongs to the MATE (multidrug and toxic compound extrusion) family of transporters that are found in bacteria, archaea and eukaryotes.[3][4]
Function
This gene is located within the Smith-Magenis syndrome region on chromosome 17.[1]
SLC47A1 belongs to the MATE family of transporters that excrete endogenous and exogenous toxic electrolytes through urine and bile.[2]
Discovery
The multidrug efflux transporter NorM from V. parahaemolyticus which mediates resistance to multiple antimicrobial agents (norfloxacin, kanamycin, ethidium bromide etc) and its homologue from E. coli were identified in 1998.[3] NorM seems to function as drug/sodium antiporter which is the first example of Na+-coupled multidrug efflux transporter discovered.[5] NorM is a prototype of a new transporter family and Brown et al. named it the multidrug and toxic compound extrusion family.[4]
See also
- MATE (Multi antimicrobial extrusion protein or multidrug and toxic compound extrusion protein)
References
- ^ a b "Entrez Gene: FLJ10847 hypothetical protein FLJ10847".
- ^ a b Otsuka M, Matsumoto T, Morimoto R, Arioka S, Omote H, Moriyama Y (2005). "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U.S.A. 102 (50): 17923–8. doi:10.1073/pnas.0506483102. PMC 1312386. PMID 16330770.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b Morita Y, Kodama K, Shiota S, Mine T, Kataoka A, Mizushima T, Tsuchiya T (1998). "NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli". Antimicrob. Agents Chemother. 42 (7): 1778–82. PMC 105682. PMID 9661020.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b Brown MH, Paulsen IT, Skurray RA (1999). "The multidrug efflux protein NorM is a prototype of a new family of transporters". Mol. Microbiol. 31 (1): 394–5. PMID 9987140.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Morita Y, Kataoka A, Shiota S, Mizushima T, Tsuchiya T (2000). "NorM of vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pump". J. Bacteriol. 182 (23): 6694–7. PMC 111412. PMID 11073914.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
Further reading
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