Solute carrier organic anion transporter family member 1B3

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Template:PBB Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 8 (OATP8) is a protein that in humans is encoded by the SLCO1B3 gene.[1]

SLCO1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.

OATP1B3 in Cancer

OATP1B3 has also been indentified as a testosterone transporter abberantly expressed in prostate cancer and implicated in prostate cancer progression.[2]

Substrates

Small molecules that are transported by SLCO1B3 include:

  • Amanitin[3]
  • Atrasentan
  • Bilirubin
  • Bosentan
  • BQ-123
  • Bromosulfophthalein (BSP)
  • CDCA-NBD
  • Cholate (CA)
  • Cholecystokinin octapeptide (CCK-8)
  • Dehydroepiandroserone-3-sulfate (DHEAS)
  • Deltorphin II
  • Demethylphalloin
  • Digoxin
  • Docetaxel
  • [D-penicillamine2,5]enkephalin (DPDPE)
  • Enalapril
  • Oestradiol-17β-glucuronide 5–25
  • Oestrone-3-sulfate
  • Fexofenadine
  • Fluvastatin
  • Fluo-3
  • Glutathione (GSH)
  • Glycocholate (GCA)
  • Glycoursodeoxycholate (GUDCA)
  • Irinotecan
  • Leukotriene C4 (LTC4)
  • Methotrexate
  • Microcystin
  • Monoglyucuronosyl
  • Olmesartan
  • Ouabain
  • Paclitaxel
  • Phalloidin
  • Pitavastatin
  • Rifampicin
  • Ro 48-5033 (Bosentan metabolite)
  • Rosuvastatin
  • SN-38
  • Taurocholate (TCA)
  • Taurochenodeoxycholate (TCDCA)
  • Taurodeoxycholate (TDCA)
  • Tauroursodeoxycholate (TUDCA)
  • Telmisartan
  • Testosterone
  • Thyroxine (T4)
  • TR-14035
  • Triiodothyronine (T3)
  • Valsartan

See also

References

  1. ^ "Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3".
  2. ^ Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, Figg WD (2008). "Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer". Clin. Cancer Res. 14 (11): 3312–8. doi:10.1158/1078-0432.CCR-07-4118. PMC 2701141. PMID 18519758. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ Hagenbuch B, Gui C (2008). "Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family". Xenobiotica. 38 (7–8): 778–801. doi:10.1080/00498250801986951. PMID 18668430. {{cite journal}}: Unknown parameter |month= ignored (help)

Further reading

  • König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Abe T, Unno M, Onogawa T; et al. (2001). "LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers". Gastroenterology. 120 (7): 1689–99. doi:10.1053/gast.2001.24804. PMID 11375950. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Ismair MG, Stieger B, Cattori V; et al. (2001). "Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver". Gastroenterology. 121 (5): 1185–90. doi:10.1053/gast.2001.28704. PMID 11677211. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Jung D, Podvinec M, Meyer UA; et al. (2002). "Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor". Gastroenterology. 122 (7): 1954–66. doi:10.1053/gast.2002.33583. PMID 12055601. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Cui Y, König J, Nies AT; et al. (2003). "Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma". Lab. Invest. 83 (4): 527–38. PMID 12695556. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Vavricka SR, Jung D, Fried M; et al. (2004). "The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma". J. Hepatol. 40 (2): 212–8. doi:10.1016/j.jhep.2003.10.008. PMID 14739090. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Hirano M, Maeda K, Shitara Y, Sugiyama Y (2004). "Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans". J. Pharmacol. Exp. Ther. 311 (1): 139–46. doi:10.1124/jpet.104.068056. PMID 15159445.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Letschert K, Keppler D, König J (2005). "Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8)". Pharmacogenetics. 14 (7): 441–52. doi:10.1097/01.fpc.0000114744.08559.92. PMID 15226676.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Yamaguchi H, Okada M, Akitaya S; et al. (2006). "Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3". J. Lipid Res. 47 (6): 1196–202. doi:10.1194/jlr.M500532-JLR200. PMID 16534140. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Ohtsuka H, Abe T, Onogawa T; et al. (2006). "Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene". J. Gastroenterol. 41 (4): 369–77. doi:10.1007/s00535-006-1784-3. PMID 16741617. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Briz O, Romero MR, Martinez-Becerra P; et al. (2006). "OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes?". J. Biol. Chem. 281 (41): 30326–35. doi:10.1074/jbc.M602048200. PMID 16877380. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Mahagita C, Grassl SM, Piyachaturawat P, Ballatori N (2007). "Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport". Am. J. Physiol. Gastrointest. Liver Physiol. 293 (1): G271–8. doi:10.1152/ajpgi.00075.2007. PMID 17412826.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Treiber A, Schneiter R, Häusler S, Stieger B (2007). "Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil". Drug Metab. Dispos. 35 (8): 1400–7. doi:10.1124/dmd.106.013615. PMID 17496208.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Muto M, Onogawa T, Suzuki T; et al. (2007). "Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma". Cancer Sci. 98 (10): 1570–6. doi:10.1111/j.1349-7006.2007.00570.x. PMID 17760952. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
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