Sodium–hydrogen antiporter 3
Sodium-hydrogen antiporter 3 also known as sodium-hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a protein that in humans is encoded by the SLC9A3 gene.[1][2]
SLC9A3 is a sodium-hydrogen antiporter. It is found in the nephron of the kidney and in the apical membrane of enterocytes of the intestine. It is primarily responsible for maintaining the balance of sodium.[3]
Regulation
Protein kinase C stimulates NHE3, while protein kinase A inhibits it. [4]
There is a specific protein functioning as an NHE3 regulator, sodium-hydrogen antiporter 3 regulator 1.
Interactions
Sodium-hydrogen antiporter 3 has been shown to interact with CHP.[5]
References
- ^ "Entrez Gene: SLC9A3 Solute carrier family 9 (sodium/hydrogen exchanger), member 3".
- ^ Brant SR, Bernstein M, Wasmuth JJ, Taylor EW, McPherson JD, Li X, Walker S, Pouyssegur J, Donowitz M, Tse CM (1993). "Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3". Genomics. 15 (3): 668–72. PMID 8096830.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ VI. Mechanisms of Salt & Water Reabsorption
- ^ 852 Walter F., PhD. Boron (2005). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 852
- ^ Inoue, Hiroki (2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. 26 (2). Japan: 148–55. doi:10.1248/bpb.26.148. ISSN 0918-6158. PMID 12576672.
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Further reading
External links
- Sodium-Hydrogen+Exchanger at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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