RHCG
Template:PBB Rh family, C glycoprotein, also known as RHCG, is a protein which in humans is encoded by the RHCG gene.[1][2]
Function
RHCG plays a critical role in ammonium handling and pH homeostasis in the kidney.[3] The structure of the RHCG protein, PDB entry 3hd6, indicates that it has a hydrophobic ammonia-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an ammonia transporter.[4]
References
- ^ "Entrez Gene: RHCG Rh family, C glycoprotein".
- ^ Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH (2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis". J. Biol. Chem. 275 (33): 25641–51. doi:10.1074/jbc.M003353200. PMID 10852913.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM (2008). "A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility". Nature. 456 (7220): 339–43. doi:10.1038/nature07518. PMID 19020613.
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Further reading
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