2'- O -methylguanosine

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Structural formula
Structural formula of 2′-O-methylguanosine
General
Surname 2'- O -methylguanosine
other names

G m (short code)

Molecular formula C 11 H 15 N 5 O 5
External identifiers / databases
CAS number 2140-71-8
PubChem 188959
ChemSpider 164190
Wikidata Q15632796
properties
Molar mass 297.27 g mol −1
Physical state

firmly

safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

2'- O -methylguanosine (G m ) is a rare nucleoside and occurs in tRNA , rRNA , mRNA and snRNA . It is a derivative of guanosine , which is methylated on the ribose .

  • A tRNA i Met from S. cerevisiae .
    2'- O -methylguanosine (here in position 9) is marked with G m .

  • A tRNA Phe from S. cerevisiae .
    2'- O -methylguanosine (here in the anticodon ) is marked with G m .

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ Patrick A. Limbach, Pamela F. Crain, James A. McCloskey: "Summary: the modified nucleosides of RNA", Nucleic Acids Research , 1994 , 22  (12), pp. 2183-2196 ( doi : 10.1093 / nar / 22.12 .2183 , PMC 523672 (free full text), PMID 7518580 ).
  3. ↑ SE Kolitz, JR Lorsch: "Eukaryotic initiator tRNA: finely tuned and ready for action", FEBS Letters , 2010 , 584  (2), pp. 396-404 ( doi : 10.1016 / j.febslet.2009.11.047 , PMC 2795131 (free full text), PMID 19925799 ).
  4. ↑ H. Shi, PB Moore : "The crystal structure of yeast phenylalanine tRNA at 1.93 Å resolution: a classic structure revisited", RNA , 2000 , 6  (8), pp. 1091-1105 ( PMC 1369984 (free full text); PMID 10943889 ).

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