Guanosine

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Structural formula
Structural formula of guanosine
General
Surname Guanosine
other names
  • G (short code)
  • 9-β- D -ribofuranosylguanine
  • 9 - [(2 R , 3 R , 4 S , 5 R ) -3,4-dihydroxy-5- (hydroxymethyl) oxolan-2-yl] -2-amino-1 H -purin-6-one
Molecular formula C 10 H 13 N 5 O 5
Brief description
  • whitish powder
  • colorless crystals (dihydrate)
External identifiers / databases
CAS number 118-00-3
EC number 204-227-8
ECHA InfoCard 100,003,844
PubChem 6802
ChemSpider 6544
DrugBank DB02857
Wikidata Q422462
properties
Molar mass 283.23 g mol −1
Physical state

firmly

Melting point

Decomposition: 239 ° C

solubility
  • slightly soluble in water
  • insoluble in ethanol and diethyl ether
  • easily soluble in acetic acid
  • soluble in dilute mineral acids
safety instructions
GHS labeling of hazardous substances
06 - Toxic or very toxic

danger

H and P phrases H: 301
P: 301 + 310
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Guanosine is a nucleoside and consists of the nucleobase guanine and the sugar β- D- ribose .

Presentation and extraction

As a component of the ribonucleic acids, it can be made from these z. B. obtained in yeast.

properties

Guanosine is part of ribonucleic acid (RNA) and forms a base pair there with cytidine . The analogue with deoxyribose is deoxyguanosine .

Structural formula of a GC base pair

Guanosine is part of the compounds GTP , GDP , of nucleic acids ( RNA , DNA - here the sugar ribose is replaced by deoxyribose ) and also a signaling molecule.

The compound is in the form of a dihydrate , which releases the water of crystallization from 110 ° C.

Analogues

Individual evidence

  1. ↑ a b Guanosine data sheet from AlfaAesar, accessed on June 7, 2007 ( PDF )(JavaScript required) .
  2. ↑ a b c d e f Entry on guanosine. In: Römpp Online . Georg Thieme Verlag, accessed on October 18, 2017.
  3. ↑ a b c d David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 90th edition. (Internet version: 2010), CRC Press / Taylor and Francis, Boca Raton, FL, Physical Constants of Organic Compounds, pp. 3-270.
  4. ↑ a b Data sheet guanosine from Sigma-Aldrich , accessed on October 16, 2016 ( PDF ).

Web links

  • Entry for guanosine in the Human Metabolome Database (HMDB) , accessed September 25, 2013.
  • Modification Summary of Guanosine in the Modomics database, accessed January 14, 2014.
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