Cytidine

Structural formula
General
Surname	Cytidine
other names	C (short code); 1-β- D- ribofuranosylcytosine; 1 - [(2 R , 3 R , 4 S , 5 R ) -3,4-dihydroxy-5- (hydroxymethyl) oxolan-2-yl] -4-aminopyrimidin-2-one;
Molecular formula	C 9 H 13 N 3 O 5
Brief description	white solid
External identifiers / databases
EC number	200-610-9
ECHA InfoCard	100,000,555
PubChem	6175
ChemSpider	5940
DrugBank	DB02097
Wikidata	Q422538
properties
Molar mass	243.22 g mol −1
Physical state	firmly
Melting point	210–220 ° C ( decomposition )
solubility	soluble in water (50 g l −1 )
safety instructions
GHS labeling of hazardous substances	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
Toxicological data	2700 mg m −3 ( LD 50 , mouse , ip )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Cytidine is a nucleoside and consists of the nucleobase cytosine and the sugar β- D- ribose . The analogue with deoxyribose is deoxycytidine .

properties

Cytidine is part of ribonucleic acid (RNA) and forms a base pair there with guanosine .

Structural formula of a GC base pair

Cytidine is an intermediate of the pyrimidine - metabolism , from the by cytidine deaminase ( EC 3.5.4.5 ) catalyzed deamination uridine , uridine by cytidine kinase ( EC 2.7.1.48 ) catalyzed phosphorylation of cytidine 5'-monophosphate (CMP) is formed. The latter is further phosphorylated via cytidine-5'-diphosphate (CDP) to cytidine-5'-triphosphate (CTP). CDP or CTP serve u. a. as building blocks in ribonucleic acid (RNA) synthesis or as an activating group in the synthesis of lipids such as lecithin , cephalin and cardiolipin .

The breakdown to cytosine takes place through the catalytic activity of pyrimidine nucleosidase ( EC 3.2.2.8 ).

Wikibooks: Biochemistry and Pathobiochemistry: Pyrimidine Metabolism - Learning and Teaching Materials

Commons : Cytidine - collection of pictures, videos and audio files

Commons : Cytidine Derivatives - Collection of Images, Videos and Audio Files

Entry for Cytidine in the Human Metabolome Database (HMDB) , accessed October 12, 2013.
Modification Summary of Cytidine in the Modomics database, accessed January 14, 2014.

↑ ^a ^b ^c ^d ^e ^f data sheet Cytidine, BioReagent, suitable for cell culture, powder, ≥99% from Sigma-Aldrich , accessed on December 21, 2019 ( PDF ).
↑ Gerhard Michal (Ed.): Biochemical Pathways - Biochemie Atlas , Spektrum, Akad. Verl., Heidelberg 1999, ISBN 3-86025-239-9 .


3-methylcytidine , m ³ C	5-methylcytidine , m ⁵ C	2'-O-methylcytidine , C _m	N ⁴ -methylcytidine , m ⁴ C	N ⁴ , N ⁴ -dimethylcytidine , m ⁴₂ C


5-azacytidine , 5-azaC