1-methylguanosine

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Structural formula
Structural formula of 1-methylguanosine
General
Surname 1-methylguanosine
other names
  • m 1 G (short code)
  • 9-β- D -ribofuranosyl-1-methylguanine
  • 9 - [(2 R , 3 S , 4 R , 5 R ) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl] -2-amino-1-methyl-purin-6-one
Molecular formula C 11 H 15 N 5 O 5
External identifiers / databases
CAS number 2140-65-0
EC number 630-718-5
ECHA InfoCard 100.159.022
PubChem 96373
ChemSpider 86996
Wikidata Q27109106
properties
Molar mass 297.27 g mol −1
Physical state

firmly

safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

1-methylguanosine (m 1 G) is a rare nucleoside and occurs in tRNA and rRNA . It consists of β- D- ribofuranose (sugar) and 1-methylguanine . It is a derivative of guanosine which is methylated in the 1-position . Base pairing is not possible due to the methylation in the 1-position . For example, 1-methylguanosine is located in tRNA Ala at position 9 between the acceptor arm and the dihydrouracil arm.

A tRNA Ala from S. cerevisiae .
1-methylguanosine here with m 1 G in.

Web links

  • Entry for 1-Methylguanosine in the Human Metabolome Database (HMDB) , accessed September 24, 2013.
  • Modification Summary of 1-Methylguanosine in the Modomics database, accessed January 14, 2014.

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ^ Patrick A. Limbach, Pamela F. Crain, James A. McCloskey: Summary: the modified nucleosides of RNA . In: Nucleic Acids Research , 1994 , 22  (12), pp. 2183-2196. doi : 10.1093 / nar / 22.12.2183 , PMID 7518580 , PMC 523672 (free full text).
  3. ^ Robert W. Holley , Jean Apgar, George A. Everett, James T. Madison, Mark Marquisee, Susan H. Merrill, John Robert Penswick, Ada Zamir: Structure of a Ribonucleic Acid . In: Science , 1965 , 147 , pp. 1462-1465. doi : 10.1126 / science.147.3664.1462 .