2'- O -ribosylguanosine phosphate

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Structural formula
Structural formula of 2′-O-ribosylguanosine phosphate
General
Surname 2'- O -ribosylguanosine phosphate
other names

Gr (p) or rGMP (short code)

Molecular formula C 15 H 22 N 5 O 12 P
External identifiers / databases
CAS number 131293-20-4
PubChem 131365
ChemSpider 116122
Wikidata Q15632693
properties
Molar mass 495.34 g mol −1
Physical state

firmly

safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

2'- O -ribosylguanosine phosphate (Gr (p) or rGMP) is a rare nucleoside and occurs in the tRNA . It is a derivative of guanosine with an additional ribose unit , which in turn is esterified with phosphoric acid .

Gr (p) was detected at position 64 of the initiator tRNA from Schizosaccharomyces pombe , Torulopsis utilis and Candida albicans . In Saccharomyces cerevisiae the related 2'-O-ribosyladenosine phosphate takes this position. The special modification (phosphoribosylation) at position 64 is therefore regarded by the authors as a characteristic of all sequenced initiator tRNAs in yeast.

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ Patrick A. Limbach, Pamela F. Crain, James A. McCloskey: "Summary: the modified nucleosides of RNA", Nucleic Acids Research , 1994 , 22  (12), pp. 2183-2196 ( doi : 10.1093 / nar / 22.12 .2183 , PMC 523672 (free full text), PMID 7518580 ).
  3. ^ Anne-Lise Glasser, Jean Desgres, Jacques Heitzler, Charles W. Gehrke, Gerard Keith: “ O- Ribosyl-phosphate purine as a constant modified nucleotide located at position 64 in cytoplasmic initiator tRNAs Met of yeasts”, Nucleic Acids Research , 1991 , 19  (19), pp. 5199-5203 ( doi : 10.1093 / nar / 19.19.5199 , PMC 328876 (free full text), PMID 1656390 ).

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