2-methyladenosine
Structural formula | |||||||||||||
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Surname | 2-methyladenosine | ||||||||||||
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Molecular formula | C 11 H 15 N 5 O 4 | ||||||||||||
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properties | |||||||||||||
Molar mass | 281.27 g mol −1 | ||||||||||||
Physical state |
firmly |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
2-methyladenosine (m 2 A) is a rare nucleoside and occurs in tRNA and rRNA . It consists of β- D- ribofuranose (sugar) and 2-methyladenine . It is a derivative of adenosine which is methylated in the 2-position . It was first isolated in 1972. It is located at position 38 of the tRNA Arg .
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ Patrick A. Limbach, Pamela F. Crain, James A. McCloskey: "Summary: the modified nucleosides of RNA", Nucleic Acids Research , 1994 , 22 (12), pp. 2183-2196 ( doi : 10.1093 / nar / 22.12 .2183 , PMC 523672 (free full text), PMID 7518580 ).
- ↑ Mineo Saneyoshi, Ziro Ohashi, Fumio Harada, Susumu Nishimura: "Isolation and characterization of 2-methyladenosine from Escherichia coli tRNA Glu 2 , tRNA Asp 1 , tRNA His 1 and tRNA Arg ", Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis , 1972 , 262 (1), pp. 1-10 ( doi : 10.1016 / 0005-2787 (72) 90212-2 ).
- ↑ K. Chakraburtty: "Primary structure of tRNA Arg II of E. coli B.", Nucleic Acids Research , 1975 , 2 (10), pp. 1787-1792 ( PMC 343546 (free full text), PMID 1103085 ).
Web links
- Modification Summary of 2-Methyladenosine in the Modomics database, accessed January 13, 2014.
- The RNA Modification Database: 2-methyladenosine , accessed September 21, 2014.