5-methoxyuridine

Structural formula
General
Surname	5-methoxyuridine
other names	mo 5 U (short code); 1-β- D -ribofuranosyl-5-methoxypyrimidine-2,4-dione; 1 - [(2 R , 3 R , 4 S , 5 R ) -3,4-dihydroxy-5- (hydroxymethyl) oxolan-2-yl] -5-methoxypyrimidin-2,4-dione;
Molecular formula	C 10 H 14 N 2 O 7
External identifiers / databases
EC number	252-609-8
ECHA InfoCard	100,047,812
PubChem	169704
Wikidata	Q15632761
properties
Molar mass	274.23 g mol −1
Physical state	firmly
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

5-methoxyuridine (mo ⁵ U) is a rare nucleoside and occurs in the tRNA . It consists of β- D- ribofuranose (sugar) and the nucleic base 5-methoxyuracil . It is a derivative of uridine .

literature

K. Murao, H. Ishikura, M. Albani, H. Kersten: On the biosynthesis of 5-methoxyuridine and uridine-5-oxyacetic acid in specific procaryotic transfer RNAs , Nucleic Acids Research , 1978 , 5 (4), p. 1273 -1281 ( PMC 342075 (free full text); PMID 418384 ).
George I. Birnbaum, Wayne JP Blonski, Frank E. Hruska: Structure and conformation of the anticodon nucleoside 5-methoxyuridine in the solid state and in solution . In: Canadian Journal of Chemistry . 61 (10), 1983, pp. 2299-2304, doi : 10.1139 / v83-399 .
George I. Birnbaum, Wayne JP Blonski, Frank E. Hruska: Structure and conformation of the anticodon nucleoside 5-methoxyuridine in the solid state and in solution . In: Canadian Journal of Chemistry . 61 (12), 1983, p. 2829, doi : 10.1139 / v83-488 .

↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ Patrick A. Limbach, Pamela F. Crain, James A. McCloskey: Summary: the modified nucleosides of RNA , Nucleic Acids Research , 1994 , 22 (12), pp. 2183-2196 ( doi: 10.1093 / nar / 22.12.2183 ; PMC 523672 (free full text); PMID 7518580 ).

Modification Summary of 5-Methoxyuridine in the Modomics database, accessed January 13, 2014.