6-monoacetylmorphine

Structural formula
General
Surname	6-monoacetylmorphine
other names	6-acetylmorphine; 6-MAM; 3-Hydroxy-6-acetyl (5 α , 6 α ) -7,8-didehydro-4,5-epoxy-17-methylmorphinan;
Molecular formula	C 19 H 21 NO 4
External identifiers / databases
EC number	621-729-6
ECHA InfoCard	100.150.555
PubChem	5462507
Wikidata	Q2406967
Drug information
Drug class	Opioid - analgesic
properties
Molar mass	327.37 g · mol -1
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

6-monoacetylmorphine is a metabolite of diacetylmorphine (heroin). In the human body, heroin is broken down into this compound with a half-life of a few minutes. Since it occurs only as a metabolite of heroin, but not of codeine or other common opiates , it is a fairly reliable proof of heroin. It is the substance most often tested for to detect heroin use, as it can be found in urine , blood and hair and has a half-life of 1 to 3 hours.

The reliable qualitative and quantitative detection of different test materials is possible after an appropriate sample preparation by chromatographic methods in coupling with mass spectrometry .

Individual evidence

↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ Burkhard Madea: Praxis forensic medicine: assessment, reconstruction, assessment . Springer, 2006, ISBN 3-540-33719-9 , pp. 455 ( limited preview in Google Book search).
↑ Thomas Geschwinde: Drugs: Market forms and modes of action . Springer DE, 2007, ISBN 3-540-43542-5 , pp. 320 ( limited preview in Google Book search).
^ Burkhard Madea: Hair analysis: Technology and interpretation in medicine and law . Deutscher Ärzteverlag, 2004, ISBN 3-7691-0437-4 , p. 139 ff . ( limited preview in Google Book search).
↑ JM Jones, MD Raleigh, PR Pentel, TM Harmon, DE Keyler, RP Remmel, AK Birnbaum: Stability of heroin, 6-monoacetylmorphine, and morphine in biological samples and validation of an LC-MS assay for delayed analyzes of pharmacokinetic samples in council In: J Pharm Biomed Anal . 74, 2013, pp. 291-297, PMID 23245263 .
↑ T. Mahdy, TH El-Shihi, MM Emara, S. Chericoni, M. Giusiani, M. Giorgi: Development and validation of a new GC-MS method for the detection of tramadol, O-desmethyltramadol, 6-acetylmorphine and morphine in blood, brain, liver and kidney of Wistar rats treated with the combination of heroin and tramadol. In: J Anal Toxicol . 36, 2012, pp. 548-559, PMID 22933659 .

[NV-1] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[Burkhard_Madea1-2] Burkhard Madea: Praxis forensic medicine: assessment, reconstruction, assessment . Springer, 2006, ISBN 3-540-33719-9 , pp. 455 ( limited preview in Google Book search).

[Thomas_Geschwinde-3] Thomas Geschwinde: Drugs: Market forms and modes of action . Springer DE, 2007, ISBN 3-540-43542-5 , pp. 320 ( limited preview in Google Book search).

[Burkhard_Madea2-4] Burkhard Madea: Hair analysis: Technology and interpretation in medicine and law . Deutscher Ärzteverlag, 2004, ISBN 3-7691-0437-4 , p. 139 ff . ( limited preview in Google Book search).

[5] JM Jones, MD Raleigh, PR Pentel, TM Harmon, DE Keyler, RP Remmel, AK Birnbaum: Stability of heroin, 6-monoacetylmorphine, and morphine in biological samples and validation of an LC-MS assay for delayed analyzes of pharmacokinetic samples in council In: J Pharm Biomed Anal . 74, 2013, pp. 291-297, PMID 23245263 .

[6] T. Mahdy, TH El-Shihi, MM Emara, S. Chericoni, M. Giusiani, M. Giorgi: Development and validation of a new GC-MS method for the detection of tramadol, O-desmethyltramadol, 6-acetylmorphine and morphine in blood, brain, liver and kidney of Wistar rats treated with the combination of heroin and tramadol. In: J Anal Toxicol . 36, 2012, pp. 548-559, PMID 22933659 .