Acrosine
| Acrosine | ||
|---|---|---|
|
||
| Ribbon model of the beta-acrosine dimer from domestic sheep ( Ovis aries ), according to PDB 1FIW | ||
| Properties of human protein | ||
| Mass / length primary structure | 324 amino acids | |
| Identifier | ||
| Gene name | ACR | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.4.21.10 , serine protease | |
| MEROPS | S01.223 | |
| Response type | Cleavage of peptide bonds | |
| Substrate | P-Arg - + - Xaa-P / P-Lys - + - Xaa-P | |
| Products | P-Arg, P-Xaa / P-Lys, P-Xaa | |
| Occurrence | ||
| Parent taxon | Mammals | |
Acrosin , also called acrosin in some publications , symbol ACR , is an enzyme from the peptidase family . The EC number is 3.4.21.10.
Occurrence
Acrosine is the major proteinase in the acrosome of mature sperm . It is a typical representative of the serine proteinases, with a specificity similar to trypsin . The inactivated precursor protein proacrosin is located in the acrosome . The active form of the enzyme causes the dissolution ( lysis ) of the zona pellucida , the protective covering of the egg cell . This allows the sperm to enter the egg.
Proacrosin is detectable for the first time in the haploid spermatids in the course of spermatogenesis .
The gene coding for the protein acrosine is located in humans on chromosome 22 gene locus q13.3.
Acrosine Associated Syndromes
A lack of acrosine, or proacrosine, leads to sterility in men .
Individual evidence
- ↑ a b acrosine. In: Online Mendelian Inheritance in Man . (English)
- ↑ S. Florke-Gerloff et al: Acrosin and the acrosome in human spermatogenesis. In: Hum Genet 65, 1983, pp. 61-67. PMID 6357995
- ↑ IM Adham et al .: Localization of human preproacrosin to chromosome 22q13-qter by somatic cell hybrid analysis. In: Cytogenet Cell Genet 51, 1989, p. 948.
- ↑ IM Adham et al: The gene encoding the human preproacrosin (ACR) maps to the q13-qter region on chromosome 22. In: Hum Genet 84, 1989, pp. 59-62. PMID 2606479
literature
- C. Keck and HM Behre: Endocrinology, Reproductive Medicine, Andrology. Georg Thieme Verlag, 2002, ISBN 3-131-07162-1 , p. 165.
- U. Klemm et al: Acrosin, the peculiar sperm-specific serine protease. In: Hum Genet 87, 1991, pp. 635-641. PMID 1937464
- MH Vazquez-Levin et al: Molecular cloning, sequencing and restriction mapping of the genomic sequence encoding human proacrosin. In: Europ J Biochem 207, 1992, pp. 23-26. PMID 1628652
- L. Howes and R. Jones: Interactions between zona pellucida glycoproteins and sperm proacrosin / acrosin during fertilization. In: J Reprod Immunol 53, 2002, pp. 181-192. PMID 11730915 (Review)
- HW Baker et al: The human acrosome reaction. ( Memento of October 24, 2008 in the Internet Archive ) In: Asian J Androl 2, 2000, pp. 172-178. PMID 11225975 (Review)