Adenylate kinase

from Wikipedia, the free encyclopedia
Adenylate kinase
Adenylate kinase
Ribbon / surface model with P1, P4-Di (adenosine-5 ′) tetraphosphate (ADP-ADP) according to PDB  2C95 . Active center (green), ADP binding site (yellow)

Existing structural data : 1z83 , 2c95

Properties of human protein
Mass / length primary structure 194 amino acids
Secondary to quaternary structure Monomer
Gene name AK1
External IDs
Enzyme classification
EC, category kinase
Response type (De-) phosphorylation
Substrate ATP + AMP
Products ADP + ADP

The enzyme adenylate kinase (AK1) (also myokinase and AMP kinase ) catalyzes the following reactions in order to maintain the balance between the phosphate acceptor ADP and the phosphate donor ATP :

  • 2 ADP → ATP + AMP

Subsequently, the hydrolysis of the ATP releases energy, which can be used in muscles or other tissues.

The reaction is also possible in the other direction if there is excess ATP and ADP is necessary as an energy store:

  • ATP + AMP → 2 ADP

At least three isoforms of the enzyme have developed in mammals ; five alleles are known in humans . The oldest form can also be found in other living things, with the exception of the archaea . In humans it is localized in all types of tissue. Adenylate kinase deficiency caused by mutation in the AK1 gene leads to a form of hemolytic anemia .

Web links

Individual evidence

  1. Swiss Institute of Bioinformatics (SIB): PROSITE documentation PDOC00104. Adenylate kinase. Retrieved September 20, 2011 .
  2. UniProt P00568