Alan Perelson

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Alan Stuart Perelson (born April 11, 1947 in Brooklyn ) is an American biophysicist .

Perelson studied at the Massachusetts Institute of Technology with a bachelor's degree in biology and electrical engineering in 1967 and received his doctorate in biophysics from Aharon Katchalsky-Katzir at the University of California, Berkeley , in 1972 (dissertation: A Network Thermodynamic Treatment of Coupled Chemical and Diffusional Processes ) . In 1973 he was acting assistant professor of medical physics at Berkeley and in 1974 a post-graduate student in the chemical engineering department at the University of Minnesota . From 1974 to 1991 he was a member of the Los Alamos National Laboratory in the department of theoretical biology and biophysics, where he was a Laboratory Fellow from 1991 to 2002 and then a Senior Fellow. From 1995 to 2001 he headed the department of theoretical biology and biophysics and from 1989 the program for theoretical immunology.

He was also Assistant Professor at Brown University in 1978/79 and is Adjunct Professor of Bioinformatics at Boston University , the University of Rochester Medical Schol (Adjunct Professor of Biostatistics and Computational Biology) and Adjunct Professor of Biology at the University of New Mexico . In 1990 he was visiting professor at the École normal supérieure in Paris.

He deals with theoretical immunology, the mathematical analysis of the immune system as an example of a complex system and network. Among other things, he dealt with the dynamics of the immune system in HIV infection .

In 1989 he received a Career Research Development Award from the National Institutes of Health. In 2017 he received the Max Delbruck Prize and in 2019 he was selected for the Gibbs Lecture . He is a member of the American Academy of Arts and Sciences (since 1999) and on the board of the Santa Fe Institute , of which he is also an external professor.

Fonts (selection)

  • with J. Doyne Farmer , Norman Packard : The immune system, adaptation, and machine learning, Physica D, Volume 22, 1986, pp. 187-204
  • Immune Network Theory, Immunology Reviews, Vol. 110, 1989, pp. 5-36
  • with DE Kirschner, R. De Boer: Dynamics of HIV infection of CD4 + T cells, Mathematical Biosciences, Volume 114, 1993, pp 81-125
  • with VA Kuznetsov, IA Makalkin, MA Taylor: Nonlinear dynamics of immunogenic tumors: parameter estimation and global bifurcation analysis, Bulletin of Math. Biology, Volume 56, 1994, pp. 295-321
  • with S. Forrest, L. Allen, R. Cherukuri: Self-nonself discrimination in a computer, Proceedings IEEE Computer Society Symposium on Research in Security and Privacy 1994
  • with DD Ho, M. Markowitz u. a .: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection, Nature, Volume 373, 1995, p. 123
  • with DD Ho, M. Markowitz u. a .: HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time, Science, Volume 271, 1996, pp. 1582-1586
  • with Ashley T. Haase u. a .: Quantitative image analysis of HIV-1 infection in lymphoid tissue, Science, Volume 274, 1996, pp. 985-989
  • with P. Essunger u. a .: Decay characteristics of HIV-1-infected compartments during combination therapy, Nature, Volume 387, 1997, p. 188
  • with G. Weisbuch: Immunology for physicists, Reviews of Modern Physics, Volume 69, 1997, p. 1219
  • with AU Neumann u. a .: Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-α therapy, Science, Volume 282, 1998, pp. 103-107
  • with X. Jin, David Ho u. a .: Dramatic rise in plasma viremia after CD8 + T cell depletion in simian immunodeficiency virus-infected macaques, Journal of Experimental Medicine, Volume 189, 1999, pp. 991-998
  • with PW Nelson: Mathematical analysis of HIV-1 dynamics in vivo, SIAM Review, Volume 41, 1999, pp. 3-44
  • with M. Furtado a. a .: Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy, New England Journal of Medicine, Volume 340, 1999, pp. 1614-1622
  • with L. Zhang u. a .: Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy, New England Journal of Medicine, Volume 340, 1999, pp. 1605-1613
  • Modeling viral and immune system dynamics, Nature Reviews Immunology, Volume 2, 2002, p. 28
  • with N. Goonetilleke u. a .: The first T cell response to transmitted / founder virus contributes to the control of acute viremia in HIV-1 infection, Journal of Experimental Medicine, Volume 206, 2009, pp. 1253-1272
  • with JF Salazar-Gonzalez a. a .: Genetic identity, biological phenotype, and evolutionary pathways of transmitted / founder viruses in acute and early HIV-1 infection, Journal of Experimental Medicine, Volume 206, 2009, pp. 1273-1289
  • The warriors within, Basic Books 2014
  • Published in: Theoretical Immunology, 2 volumes, Santa Fe Institute 2018

Web links

Individual evidence

  1. ↑ Birth and career data according to American Men and Women of Science , Thomson Gale 2004
  2. ↑ Alan Perelson in the Mathematics Genealogy Project (English)Template: MathGenealogyProject / Maintenance / id used
  3. ↑ Book of Members 1780 – present, Chapter P. (PDF; 649 kB) In: American Academy of Arts and Sciences (amacad.org). Accessed July 23, 2018 .
personal data
SURNAME Perelson, Alan
ALTERNATIVE NAMES Perelson, Alan Stuart (full name)
BRIEF DESCRIPTION American biophysicist
DATE OF BIRTH April 11, 1947
PLACE OF BIRTH Brooklyn