Anna Akhmanova
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Anna Sergeevna Akhmanova ( Russian Анна Сергеевна Ахманова ; born May 11, 1967 in Moscow ) is a cell biologist of Russian origin who is a professor at the University of Utrecht .
Anna Akhmanova studied biochemistry and molecular biology at Lomonossow University and received her doctorate in 1997 from Radboud University Nijmegen . As a post-doctoral student she was at the University of Nijmegen and at the Erasmus Medical Center of the University of Rotterdam , where she had her own research group from 2001. In 2011 she became Professor of Cell Biology at the University of Utrecht.
She deals with the cytoskeleton , especially the microtubules , their dynamics and their role in embryology and diseases. Her group also examines cell cultures in three-dimensional matrices with high-resolution microscopy. The dynamics at the protein level and vesicle transport are also examined . In particular, she investigated proteins that interact with the plus ends of microtubules (Microtubule Plus End Tracking Proteins, + TIP) and regulate the dynamics of the microtubules and interact with various cell structures ( actin skeleton, focal adhesion , cell-cell contact). More recently, they have also studied the minus-end microtubule proteins (-TIP), which are less well understood, and investigated vesicle transport associated with microtubules. The motor proteins kinesin and dynein couple to the microtubules and organelles or vesicles and ensure long-range transport along them, with kinesin binding to the plus end and dynein to the minus end of the microtubules. Akhmanova's group investigated dynein and its link formation, the interaction with kinesin and the signaling pathways associated with motor proteins. The research has implications for the study of abnormal cell proliferation, cell division, and the intracellular transport of pathogens (infectious and neurodegenerative diseases).
From 2011 to 2017 she was head of the Dutch Society for Microscopy.
She is a member of the Royal Netherlands Academy of Sciences (2015) and the European Molecular Biology Organization (EMBO). In 2018 she received the most important Dutch science award , the Spinoza Prize .
She works in part with Marileen Dogterom , with whom she received an ERC Synergy Grant.
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| personal data | |
|---|---|
| SURNAME | Akhmanova, Anna |
| ALTERNATIVE NAMES | Akhmanova, Anna Sergeevna (full name); Ахманова, Анна Сергеевна |
| BRIEF DESCRIPTION | Russian-Dutch cell biologist |
| DATE OF BIRTH | May 11, 1967 |
| PLACE OF BIRTH | Moscow |