Anne-Marie Staub

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Anne-Marie Staub (born November 13, 1914 in Pont-Audemer , † 2012 in Saint-Germain-en-Laye ) was a French biochemist.

Life

Staub came from a family connected to Louis Pasteur . Her grandfather was Pasteur's best man in 1882 and her father André Staub (1883–1967) worked at the Pasteur Institute from 1906 until his retirement in 1951 . Dust played the piano as a teenager and considered becoming a pianist for a while. From 1930 she studied science and mathematics at the Sorbonne . For a while she considered caring for lepers for religious reasons. In 1935/36 she attended the microbiology course at the Pasteur Institute, which she joined in 1936 and where she received her doctorate in 1939 in the group of Daniel Bovet . During this time, Anne-Marie Staub was part of the group in Ernest Fourneau's laboratory with Bovet at the Pasteur Institute that developed the first antihistamines , and this was also the subject of her dissertation . Its active ingredient F 929 was toxic, however, and it was not until 1942 that Bernard Halpern developed the first therapeutically usable antihistamines at Rhône-Poulenc . At that time she turned to other subjects (Bovet had gone to his Swiss homeland in 1939) and was in her father's laboratory, who developed vaccines for animals.

From 1941 she worked for Pierre Grabar , switched to immunochemistry and isolated various antigens (including anthrax ). Her brother was in the Resistance and was killed by the German occupation forces in 1944. In 1946 she went to London for three years . She worked at the Lister Institute and received a grant from the Medical Research Institute while continuing her anthrax research. Back at the Pasteur Institute, she set up an immunochemical laboratory for vaccines (headed from 1953). She dealt in particular with salmonella. In 1954 she was absent for a year because of viral meningitis . In the 1960s she researched endotoxin antigens, which are lipo-polysaccharides . She characterized several of these antigens immunochemically, including Tyvelose (from Salmonella typhi ). From 1960 to 1974 she held courses on immunology at the Pasteur Institute with Marcel Raynaud , and from 1960 to 1977 she headed the laboratory for bacterial antigens. From 1955 to 1975 she worked with the Max Planck Institute in Freiburg ( Otto Lüderitz ) and was made a member for life there. In 1969 she received the Paul Ehrlich and Ludwig Darmstaedter Prize . In 1973 she became a Knight of the Legion of Honor .

At the age of 62 she left science and devoted herself to religious tasks. Since 1960 she has regularly withdrawn to the La Part Dieu spiritual center in Poissy .

Fonts

  • with Marcel Raynaud: Cours d'immunologie générale et de sérologie de l'Institut Pasteur. 5th edition, Paris 1967

literature

  • Renate Strohmeier: Lexicon of natural scientists and women of Europe. Verlag Harri Deutsch, Thun and Frankfurt am Main 1998, ISBN 3-8171-1567-9 , pp. 261–262 ( digitized version )

Web links

Individual evidence

  1. ^ Anne-Marie Staub (1914-2012) - Notice biographique in pasteur.fr (French) ( Memento of September 4, 2013 in the Internet Archive )
  2. ↑ D. Bovet and A.-M. Dust: Action protectrice des éthers phenoliques au cours de l'intoxication histaminique. In: Comptes Rendus Hebdomadaires de la Société de Biologie et de ses Filiales. 124, 1937, pp. 547-549; AT THE. Staub and D. Bovet: Action de la thymoxyéthyldiéthylamine (929 F.) et des éthers phénoliques sur le choc anaphylactique du cobaye. In: Comptes Rendus Hebdomadaires de la Société de Biologie et de ses Filiales. 125, 1937, pp. 818-821; AT THE. Dust: Recherches sur quelques bases synthétiques antagonistes de l'histamine. In: Annales de l'Institut Pasteur. Volume 63, 1939, pp. 400-436.
personal data
SURNAME Dust, Anne-Marie
BRIEF DESCRIPTION French biochemist
DATE OF BIRTH November 13, 1914
PLACE OF BIRTH Pont-Audemer
DATE OF DEATH 2012
Place of death Saint-Germain-en-Laye