Anne Spang

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Anne Spang, 2011

Anne Spang (born November 29, 1967 in Wadern ) is a German biochemist / cell biologist and teaches and researches at the Biozentrum of the University of Basel , Switzerland .

Life

Anne Spang studied chemical technology at the University of Applied Sciences in Darmstadt and biochemistry at the Université Paris VI in France . She did her doctorate in 1996 at the Max Planck Institute for Biochemistry in Martinsried . She then did research as a postdoctoral fellow at the University of California, Berkeley , USA. From 1999 to 2006 she was a research group leader at the Friedrich Miescher Laboratory of the Max Planck Society in Tübingen. Spang has been Professor of Biochemistry and Cell Biology at the Biozentrum of the University of Basel since 2005 .

Act

Anne Spang researches the basics of intracellular transport . Spang gained international renown for her discovery that there is a maturation process from the early to the late endosome. In the nematode Caenorhabditis elegans , she identified SAND-1 as the central switch that controls ripening. In addition, she showed that ArfGAP proteins are important for the uptake of cargo in transport vesicles and that COPI components play a role in mRNA transport and mRNA metabolism. Her findings are important for understanding many diseases that are based on defects in the localization of proteins and mRNA in the cell, such as Alzheimer's disease , cystic fibrosis , lysosomal storage diseases and cancer .

Awards

  • 2010: Binder Innovation Prize
  • 2009: Elected member of the European Molecular Biology Organization (EMBO)
  • 2005: Walther Flemming Medal of the German Society for Cell Biology
  • 2002: EMBO Young Investigator

List of publications

  • Kilchert, C. and A. Spang. (2011). Co-translational localization of ABP140 mRNA to the distal pole of yeast cells. EMBO J. 30: 3567-80
  • Kilchert, C., J. Weidner, C. Prescianotto-Baschong, and A. Spang. (2010). Defects in the secretory pathway and high Ca2 + induce multiple P-bodies. Mol. Biol. Cell. 21: 2624-2638
  • Poteryaev, D., S. Datta, K. Ackema, M. Zerial, and A. Spang. (2010). Identification of the switch in early-to-late endosome transition. Cell 141: 497-508
  • Poteryaev, D., H. Fares, B. Bowerman, and A. Spang. (2007) Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic. EMBO J. 26: 301-312
  • Schmutz, C., J. Stevens and A. Spang. (2007) Functions of the novel RhoGAPs RGA-3 and RGA-4 in the germ line and in the early embryo of C. elegans. Development 134: 3495-3505
  • Trautwein, M., C. Schindler, R. Gauss, J. Dengjel, E. Hartmann, and A. Spang. (2006) Arf1p, Chs5p, and the ChAPs are required to bud specialized vesicles from the Golgi in Saccharomyces cerevisiae. EMBO J. 25: 943-954
  • Poteryaev, D., JM Squirrell, JG White, and A. Spang. (2005). ER dynamics in the early C. elegans embryo require homotypic membrane fusion and the actin cytoskeleton. Mol. Biol. Cell. 16: 2139-2153
  • Trautwein, M., J. Dengjel, M. Schirle, and A. Spang. (2004). Arf1p provides an unexpected link between vesicular traffic and mRNA transport in Saccharomyces cerevisiae. Mol. Biol. Cell , 15: 5021-5037
  • Lewis, SM, PP Poon, RA Singer, GC Johnston, and A. Spang. (2004). The Arf-GAP Glo3 is required for the generation of COPI vesicles. Mol. Biol. Cell , 15: 4064-4072
  • Kamena, F. and A. Spang. (2004). Tip20p provides directionality to transport by inhibiting back fusion of COPII vesicles with the endoplasmic reticulum. Science , 304: 286-289
  • Rein, U., U. Andag, R. Duden, H.-D. Schmitt, and A. Spang. (2002). ARF-GAP mediated interaction between the ER-Golgi v-SNAREs and the COPI coat. J. Cell Biol. , 157: 395-404
  • Spang, A., and R. Schekman. (1998) Reconstitution of retrograde transport from the Golgi to the ER in vitro. J. Cell Biol . 143: 589-599
  • Spang, A., K. Matsuoka, S. Hamamoto, R. Schekman, and L. Orci. (1998). Coatomer, Arf1p, and nucleotide are required to bud COPI-coated vesicles from large synthetic liposomes. PNAS , 95: 11199-11204.
  • Spang, A., S. Geissler, K. Grein, and E. Schiebel. (1996). The γ-tubulin-like Tub4p of Saccharomyces cerevisiae is associated with the spindle pole body substructures that organize microtubules and is required for mitotic spindle formation. J. Cell Biol ., 134: 429-441.
  • Spang, A., I. Courtney, U. Fackler, M. Matzner, and E. Schiebel. (1993). The calcium-binding protein cell division cycle 31 of Saccharomyces cerevisiae is a component of the half bridge of the spindle pole body. J. Cell Biol. , 123: 405-416.

Web links

Individual evidence

  1. ↑ Curriculium Vitae unibas.ch. Retrieved July 27, 2020.
  2. ^ Anne Spang research group receives Sinergia grant from the SNSF
  3. ^ Research group
  4. ^ Binder Innovation Prize for Anne Spang
  5. ^ Academia Net
  6. ↑ EMBO Annual Report ( Memento of the original dated June 11, 2012 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. (PDF; 1.5 MB)  @1@ 2Template: Webachiv / IABot / embc.embo.org
personal data
SURNAME Spang, Anne
BRIEF DESCRIPTION German biochemist / cell biologist and professor at the Biozentrum of the University of Basel, Switzerland
DATE OF BIRTH November 29, 1967
PLACE OF BIRTH Waders