Biometallic organic chemistry

The bioorganometallic chemistry is a branch of chemistry dealing with the investigation of biologically active molecules is concerned, which is a direct carbon - metal or carbon - semi-metal bond have. These can be classic transition metal complexes with ligands such as carbon monoxide , ethylene or cyclopentadiene or biomolecules such as amino acids , sugars or antibodies that have a direct carbon-metal bond and play a role in biological processes.

It includes elements from organometallic chemistry , biochemistry and medicine . Naturally occurring organic biometallic molecules include some enzymes and proteins . The goals of organometallic chemistry include the development of new drugs and the study of the toxicology of organometallic compounds.

history

Trimeric form of arsphenamine

After there had already been studies on the effects of mercury , iodine and arsenic as possible remedies for the treatment of syphilis, a milestone in biometallic organic chemistry followed in 1909 with the development of arsphenamine by Paul Ehrlich and Sahachiro Hata , which also marked the beginning of chemotherapy . The discovery sparked a wave of research in the field of bio-organometallic arsenic compounds, which led to the development of other therapeutics such as neosalvarsan (which was also combined with mercury) and solusalvarsan.

The discovery of the nature of vitamin B12 in 1948 by Karl August Folkers marks another high point in history. The discovery of the cytostatic properties of cisplatin finally followed in the 1960s .

literature

• Gérard Jaouen: Bioorganometallics: Biomolecules, Labeling, Medicine , 2006 Wiley-VCH Verlag, Weinheim ISBN 3-527-30990-X

Individual evidence

1. ↑ Sh. Dohi: About the influence of remedies for syphilis (mercury, iodine and arsenic) on the immune substances of the organism (hemolysins, agglutinins and precipitins). In: Journal for Experimental Pathology and Therapy. 6, 1909, p. 171, doi : 10.1007 / BF02656766 .
2. ↑ K. Williams: The introduction of 'chemotherapy' using arsphenamine - the first magic bullet. In: JRSM. 102, 2009, p. 343, doi : 10.1258 / jrsm.2009.09k036 .
3. ↑ Kurt Bleckmann: About combined Neosalvarsan mercury treatment of congenital syphilis. Medical dissertation Strasbourg 1916.
4. ^ Edward L Rickes: Vitamin B12, a cobalt complex. In: Science , 108.2797 (1948), pp. 134-134.
5. ^ Bernhard Lippert, Wolfgang Beck: Platinum complexes in cancer therapy. In: Chemistry in Our Time. 17, 1983, p. 190, doi : 10.1002 / ciuz.19830170604 .