Bisindolyl maleimide 1

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Structural formula
Structural formula of bisindolylmalimide 1
General
Surname Bisindolyl maleimide 1
other names
  • 3- ( N - [Dimethylamino] propyl-3-indolyl) -4- (3-indolyl) maleimide
  • 3- [1- [3- (Dimethylamino) propyl] 1 H -indol-3-yl] -4- (1 H -indol-3-yl) 1 H -pyrrole-2,5-dione
  • 3- [1- (3-Dimethylaminopropyl) indol-3-yl] -4- (1 H -indol-3-yl) -1 H -pyrrole-2,5-dione
  • Bisindolyl maleimides I.
  • GF109203X
Molecular formula C 25 H 24 N 4 O 2
Brief description

orange solid

External identifiers / databases
CAS number 133052-90-1
EC number 603-702-0
ECHA InfoCard 100.122.321
PubChem 2396
ChemSpider 2303
DrugBank DB03777
Wikidata Q866357
properties
Molar mass 412.48 g mol −1
Physical state

firmly

solubility
  • soluble in DMSO (~ 1 mg / ml)
  • practically insoluble in water
safety instructions
GHS labeling of hazardous substances
08 - Dangerous to health

Caution

H and P phrases H: 351
P: 280
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Bisindolylmalimide 1 is a chemical compound from the group of bisindolylmaleimides .

properties

Bisindolylmalimide 1 is an orange crystalline solid that is practically insoluble in water.

use

Bisindolylmalimide 1 is used as a highly selective inhibitor of all protein kinase C isoforms and as a mild inhibitor of GSK-3.

Individual evidence

  1. ↑ a b c d data sheet bisindolylmaleimide 1 at AlfaAesar, accessed on July 14, 2017 ( PDF )(JavaScript required) .
  2. ↑ a b c d data sheet GF 109203X, synthetic, ≥90% (HPLC) from Sigma-Aldrich , accessed on July 14, 2017 ( PDF ).