Bucatoxin

Bucatoxin
other names	BuK-alpha-Tx, BukaTx, BKTx
Mass / length primary structure	65 amino acids , 7,226 Da
Identifier
External IDs	UniProt : P82815 ;

Bukatoxin is a toxin from the scorpion Buthus martensi Karsch .

properties

Bukatoxin is a peptide and binds to sodium channels , which means that they remain open permanently and action potentials are extended. Bukatoxin is one of the scorpion toxins with four disulfide bridges and has cysteines at positions 12, 16, 22, 26, 36, 46, 48 and 63. It presumably inhibits the inactivation of sodium channels by binding binding site 3.

Web links

MeSH bucatoxin

Individual evidence

↑ ^a ^b K. N. Srinivasan, S. Nirthanan, T. Sasaki, K. Sato, B. Cheng, MC Gwee, RM Kini, P. Gopalakrishnakone: Functional site of bukatoxin, an alpha-type sodium channel neurotoxin from the Chinese scorpion (Buthus martensi Karsch) venom: probable role of the (52) PDKVP (56) loop. In: FEBS letters. Volume 494, Number 3, April 2001, pp. 145-149, PMID 11311230 .
↑ WA Catterall, S. Cestèle, V. Yarov-Yarovoy, FH Yu, K. Konoki, T. Scheuer: Voltage-gated ion channels and gating modifier toxins. In: Toxicon: official journal of the International Society on Toxinology. Volume 49, Number 2, February 2007, pp. 124-141, doi : 10.1016 / j.toxicon.2006.09.022 , PMID 17239913 .

[Srinivasan-1] K. N. Srinivasan, S. Nirthanan, T. Sasaki, K. Sato, B. Cheng, MC Gwee, RM Kini, P. Gopalakrishnakone: Functional site of bukatoxin, an alpha-type sodium channel neurotoxin from the Chinese scorpion (Buthus martensi Karsch) venom: probable role of the (52) PDKVP (56) loop. In: FEBS letters. Volume 494, Number 3, April 2001, pp. 145-149, PMID 11311230 .

[2] WA Catterall, S. Cestèle, V. Yarov-Yarovoy, FH Yu, K. Konoki, T. Scheuer: Voltage-gated ion channels and gating modifier toxins. In: Toxicon: official journal of the International Society on Toxinology. Volume 49, Number 2, February 2007, pp. 124-141, doi : 10.1016 / j.toxicon.2006.09.022 , PMID 17239913 .