CD94

from Wikipedia, the free encyclopedia
Natural killer cells antigen CD94
Natural killer cells antigen CD94
according to PDB  1B6E
other names

KP43, Killer cell lectin-like receptor subfamily D member 1, KLRD1, NK cell receptor, CD94

Existing structure data : PDB  3BDW , PDB  3CDG

Properties of human protein
Mass / length primary structure 179 amino acids , 20,513 Da
Identifier
External IDs
Orthologue (human)
Entrez 3824
Ensemble ENSG00000134539
UniProt Q13241
Refseq (mRNA) NM_001114396.2
Refseq (protein) NP_001107868.2
PubMed search 3824

CD94 (synonym Natural killer cells antigen CD94 ) is a surface protein from the group of killer cell lectin-like receptors .

properties

CD94 is produced by NK cells and some subtypes of cytotoxic T cells . It forms a heterodimer with a member of the NKG2 family and is then the receptor for recognizing whether neighboring cells have certain HLA-E molecules on their surface and are thus recognized as 'self'. This is done according to the missing-self hypothesis . In this way, exogenous cells (and the body's own tumor cells without HLA-E) can be recognized due to the lack of HLA-E and an immune response can be triggered against them. CD94 is responsible for the detection of tumor cells without HLA-E, which due to their origin generally have few antigens for an adaptive immune response . Furthermore , CD94 binds to KLRC2 . CD94 is glycosylated , a type II membrane protein and a lectin . Different isoforms are formed from CD94 . The withdrawal of the CD94 from the cell membrane probably takes place through macropinocytosis .

Web links

Individual evidence

  1. ↑ F. Borrego, M. Masilamani, AI Marusina, X. Tang, JE Coligan: The CD94 / NKG2 family of receptors: from molecules and cells to clinical relevance. In: Immunologic research. Volume 35, Number 3, 2006, pp. 263-278, doi : 10.1385 / IR: 35: 3: 263 , PMID 17172651 .
  2. ↑ Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH: Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits . In: Journal of Immunology . 157, No. 11, Dec 1996, pp. 4741-5. PMID 8943374 .
  3. ↑ Ding Y, Sumitran S, Holgersson J: Direct binding of purified HLA class I antigens by soluble NKG2 / CD94 C-type lectins from natural killer cells . In: Scandinavian Journal of Immunology . 49, No. 5, May 1999, pp. 459-65. doi : 10.1046 / j.1365-3083.1999.00566.x . PMID 10320637 .
  4. ↑ G. Peruzzi, M. Masilamani, F. Borrego, JE Coligan: Endocytosis as a mechanism of regulating natural killer cell function: unique endocytic and trafficking pathway for CD94 / NKG2A. In: Immunologic research. Volume 43, number 1-3, 2009, pp. 210-222, doi : 10.1007 / s12026-008-8072-7 , PMID 18979076 , PMC 2752144 (free full text).