COL15A1
| Collagen type XV, alpha 1 | ||
|---|---|---|
| other names |
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| Properties of human protein | ||
| Mass / length primary structure | 1,388 amino acids , 141,720 Da | |
| Identifier | ||
| Gene name | COL15A1 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Euteleostomi , Ecdysozoa | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 1306 | 12819 |
| Ensemble | ENSG00000204291 | ENSMUSG00000028339 |
| UniProt | P39059 | O35206 |
| Refseq (mRNA) | NM_001855 | NM_009928 |
| Refseq (protein) | NP_001846.3 | NP_034058.2 |
| Gene locus | Chr 9: 98.94 - 99.07 Mb | Chr 4: 47.21 - 47.31 Mb |
| PubMed search | 1306 |
12819
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Collagen type XV, alpha 1 is a collagen that the gene COL15A1 is encoded. It forms homotrimers , which in turn form type XV collagen fibrils .
properties
The trimerization domain of collagen type XV, alpha 1 consists of three monomers , each of which consists of four β-sheets and an α-helix . This domain of the class of multiplexins (COL15A1 and COL18A1 ) represents a three-dimensional fold, which has a high sequence variability and thus enables a structural integrity, which is necessary for a dense and efficient trimerization.
COL15A1 is able to connect the basement membrane with the loose connective tissue . It stabilizes microvessels and muscle cells in the heart and skeletal muscle . It can also inhibit angiogenesis .
It can bind to fibronectin , laminin and vitronectin , and also to the collagen / gelatin-binding domain of fibronectin. COL15A1 inhibits the adhesion and cell migration of fibrosarcoma cells when they are in the fibronectin-containing matrices.
Web links
Individual evidence
- ↑ Jacqueline A. Wirz, Sergei P. Boudko, Thomas F. Lerch, Michael S. Chapman, Hans Peter Bächinger: Crystal Structure of the Human Collagen XV Trimerization Domain: A Potent Trimerizing Unit Common to Multiplexin Collagens . In: Matrix Biol . 30, No. 1, January 2011, pp. 9-15. doi : 10.1016 / j.matbio.2010.09.005 . PMID 20932905 . PMC 3048825 (free full text).
- ↑ Merja Hurskainen, Florence Ruggiero, Pasi Hägg, Taina Pihlajaniemi, Pirkko Huhtala: Recombinant Human Collagen XV Regulates Cell Adhesion and Migration . In: J Biol Chem . 285, No. 8, February 19, 2010, pp. 5258-5265. doi : 10.1074 / jbc.M109.033787 . PMID 20040604 . PMC 2820754 (free full text).