CREB binding protein

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CREB binding protein

Existing structural data: s. UniProt

Properties of human protein
Mass / length primary structure 2442 amino acids
Identifier
Gene name CREBBP
External IDs
Enzyme classification
EC, category 2.3.1.48 ,  acetyltransferase
Response type Transfer of an acetyl group
Substrate Histone + acetyl-CoA
Products Acetylhistone + CoA
Occurrence
Homology family CREBBP
Parent taxon Euteleostomi

The C REB B inding P rotein (CREB binding protein), short- CBP is a coactivator of transcription .

CBP creates a connection between the transcription factor CREB and the starting point of transcription by acting as a histone acetyltransferase (HAT, EC  2.3.1.48 ), changing the chromatin structure, which is thereby loosened. CBP shows homologies to protein p300, which also acts as HAT. CBP and p300 acetylate preferentially the histones H3 and H4.

CBP is a coactivator of a general nature and interacts e.g. B. also with transcription factors .

structure

Structure CREBBP de.svg

Clinical significance

Mutations in this gene are responsible for Rubinstein-Taybi Syndrome (RTS).

See also

Individual evidence

  1. ↑ Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ: Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP . In: Nature . 376, No. 6538, July 1995, pp. 348-51. bibcode : 1995Natur.376..348P . doi : 10.1038 / 376348a0 . PMID 7630403 .

literature

  • Rolf Knippers: Molecular Genetics . 9th edition. Georg Thieme Verlag, 2006, ISBN 3-13-477009-1
  • Goldman PS, Tran VK, Goodman RH: The multifunctional role of the co-activator CBP in transcriptional regulation. . In: Recent Prog. Horm. Res. . 52, 1997, pp. 103-19; discussion 119-20. PMID 9238849 .
  • Marcello A, Zoppé M, Giacca M: Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. . In: IUBMB Life . 51, No. 3, 2002, pp. 175-81. doi : 10.1080 / 152165401753544241 . PMID 11547919 .
  • Matt T: Transcriptional control of the inflammatory response: a role for the CREB-binding protein (CBP). . In: Acta Med. Austriaca . 29, No. 3, 2002, pp. 77-9. doi : 10.1046 / j.1563-2571.2002.02010.x . PMID 12168567 .
  • Combes R, Balls M, Bansil L, et al. : An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991). . In: Alternatives to laboratory animals: ATLA . 30, No. 4, 2002, pp. 365-406. PMID 12234245 .
  • Minghetti L, Visentin S, Patrizio M, et al. : Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions. . In: Neurochem. Res. . 29, No. 5, 2004, pp. 965-78. doi : 10.1023 / B: NERE.0000021241.90133.89 . PMID 15139295 .
  • Cinema T, Pavlakis GN: partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1 . In: DNA Cell Biol . 23, No. 4, 2004, pp. 193-205. doi : 10.1089 / 104454904773819789 . PMID 15142377 .
  • Greene WC, Chen LF: Regulation of NF-kappaB action by reversible acetylation. . In: Novartis Found. Symp . 259, 2004, pp. 208-17; discussion 218-25. doi : 10.1002 / 0470862637.ch15 . PMID 15171256 .
  • Liou LY, Herrmann CH, Rice AP: HIV-1 infection and regulation of Tat function in macrophages. . In: Int. J. Biochem. Cell Biol . 36, No. 9, 2005, pp. 1767-75. doi : 10.1016 / j.biocel.2004.02.018 . PMID 15183343 .
  • Pugliese A, Vidotto V, Beltramo T, et al. : A review of HIV-1 Tat protein biological effects. . In: Cell Biochem. Funct. . 23, No. 4, 2005, pp. 223-7. doi : 10.1002 / cbf.1147 . PMID 15473004 .
  • Bannwarth S, Gatignol A: HIV-1 TAR RNA: the target of molecular interactions between the virus and its host. . In: Curr. HIV Res . 3, No. 1, 2005, pp. 61-71. doi : 10.2174 / 1570162052772924 . PMID 15638724 .
  • Le Rouzic E, Benichou S: The Vpr protein from HIV-1: distinct roles along the viral life cycle. . In: Retrovirology . 2, 2006, p. 11. doi : 10.1186 / 1742-4690-2-11 . PMID 15725353 . PMC 554975 (free full text).
  • Gibellini D, Vitone F, Schiavone P, Re MC: HIV-1 tat protein and cell proliferation and survival: a brief review. . In: New Microbiol. . 28, No. 2, 2005, pp. 95-109. PMID 16035254 .
  • Hetzer C, Dormeyer W, Schnölzer M, Ott M: Decoding Tat: the biology of HIV Tat posttranslational modifications. . In: Microbes Infect. . 7, No. 13, 2006, pp. 1364-9. doi : 10.1016 / j.micinf.2005.06.003 . PMID 16046164 .
  • Peruzzi F: The multiple functions of HIV-1 Tat: proliferation versus apoptosis. . In: Front. Biosci. . 11, 2006, pp. 708-17. doi : 10.2741 / 1829 . PMID 16146763 .