Candida parapsilosis

Candida parapsilosis
Systematics
Subdivision : Saccharomycotina Class : Saccharomycetes Order : Real yeast (Saccharomycetales) incertae sedis Genre : Candida Type : Candida parapsilosis
Scientific name
Candida parapsilosis
( Ashford ) Langeron & Talice

Candida parapsilosis ( synonym : Candida parakrusei ) is an asexual diploid pathogenic yeast that has become an important factor in sepsis and wound and tissueinfectionsin immunocompromised patients andcausesabout 15% of Candida infections. Strains of Candida parapsilosis have historically been classified into Group I, II, or III on the basis of molecular fingerprint. The immune system is an important factor in Candida parapsilosis infections. In contrast to Candida albicans and Candida tropicalis , Candida parapsilosis is not an obligatory human pathogen, but has also been isolated from non-human sources such as domestic animals, insects and soil. Candida parapsilosis is also a normal human commensal and it is one of the most isolated fungi from human hands. Candida parapsilosis tends to form biofilms and is then more difficult to treat.

There are various risk factors that support the fungus in colonizing the human body. Immunosuppressed individuals with AIDS / HIV, oncological patients, newborns, operated patients and elderly patients, especially after intestinal operations and intestinal diseases, have a high risk of infection with Candida parapsilosis . As early as 1968, Blank u. a. Carcinogenic properties found in Candida parapsilosis in mice. With systemic infection, Candida parapsilosis can infect the central nervous system as well as the muscles.

Well-known clinical pictures are endocarditis after cardiac catheters or cardiovascular interventions, peritonitis after peritoneal dialysis , endophthalmitis after lens implantation, septic arthritis, nosocomial infection , pneumonia (rarely), nail, corneal and skin mycoses, infestation of the gastrointestinal tract.

Culture

Candida parapsilosis grows on Sabouraud agar as white to beige colonies that are smooth and shiny to slightly wrinkled. On RAT, pseudomycelium is formed from chains of long cells with clusters of blastospores attached.

genetics

The molecules of mitochondrial DNA (mtDNA) are packaged in nucleic acid-protein complexes, also known as mitochondrial nucleoids (mt nucleoids). Investigations of the band intensities after DNA staining led to an estimate that C. parapsilosis contains 14 chromosomes (7 pairs) with a total genome size of around 26.3 Mb (Doi et al. 1992).

treatment

This article or the following section is not adequately provided with supporting documents ( e.g. individual evidence ). Information without sufficient evidence could be removed soon. Please help Wikipedia by researching the information and including good evidence.

There is currently no consistent medical opinion on the treatment of Candida parapsilosis . Historically, amphotericin B was used. Miconazole , nystatin , terbinafine and triazoles such as fluconazole , voriconazole and posaconazole are modern alternatives.

literature

• M. Weiss, U. Wintergerst, BH Belohradsky: Systemic fungal infections . Springer publishing house
• cmpt.ca (PDF)
• W. Gerz: Biological preparations for diagnosis and therapy in AK practice . 2002
• H Hahn, SHE Kaufmann, TF Schulz, S Suerbaum: Medical microbiology and infectology . 6. complete revised Ed. Springer, Heidelberg, pp. 597-601
• S. Nolting: Mycoses of the digestive tract . 2nd edition Medi, Hamburg
• Nosek-Zuzana-Holesova-Kosa-Gacser-Tomaska: Biology and genetics of the pathogenic yeast Candida parapsilosis . Springer-Verlag, 2009
• Candida parapsilosis in very light births. PMID 17337658

Web links

• Genome research of Candida Parapsilosis
• Targeted gene deletion in Candida parapsilosis
• Candida parapsilosis Characterization in an Outbreak Setting
• A Genome Sequence Survey
• Candida parapsilosis sequencing

Individual evidence

1. ↑ sanger.ac.uk 3 groups
2. ↑ cancerres.aacrjournals.org cancer
3. ↑ Weems 1992; Trofa et al. 2008
4. ↑ laborlexikon.de clinical pictures
5. ↑ Candida parapsilosis at doctorfungus.org ( Memento of the original from December 13, 2013 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. 
6. ↑ pfdb.net ( Memento of the original from December 15, 2013 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Image of Candida parapsilosis on culture dish  
7. ↑ Blastospore Grapes flickr.com
8. ↑ mic.sgmjournals.org ( Memento of the original from May 13, 2009 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. 
9. ↑ Biology and genetics (PDF) springerlink.com
10. ↑ broadinstitute.org
11. ↑ cgob.ucd.ie  ( page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice. Proteins  
12. ↑ zct-berlin.de