Carlo M. Croce

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Carlo Maria Croce (born December 17, 1944 in Milan ) is an Italian -born American doctor who deals with cancer research and especially the genetics of cancer diseases.

Croce studied medicine at La Sapienza University in Rome , where he received his doctorate in 1969. From 1970 he was at the Wistar Institute for Anatomy and Biology in Philadelphia , where he was until 1988 and professor (from 1976, 1980 to 1988 Wistar Professor of Human Genetics at the University of Pennsylvania , 1987 to 1991 Wistar Professor of Pediatrics at Children's Hospital in Philadelphia) and became the deputy director of the institute. From 1988 to 1991 he was Director of the Fels Institute for Cancer Research and Molecular Biology at Temple University and Professor of Pathology and Medicine, and from 1991 to 2004 Director of the Kimmel Cancer Institute at Thomas Jefferson University in Philadelphia. From 2004 he was Director of the Institute of Genetics, John W. Wolfe Professor of Human Cancer Genetics, and Director of the Human Cancer Genetics Program at Ohio State University . He is head of the Faculty of Molecular Virology, Immunology, and Medical Genetics.

In the 1970s and 1980s, at the Wistar Institute, he identified and localized a number of oncogenes (BCL2, BCL1, MYC, ALL1, LATS1, FHIT) and discovered chromosal translocations as the cause of the deregulation of oncogenes in many leukemias and lymphomas . He discovered that in CLL, the most common form of leukemia, the function of the micro-RNA genes miR15 and 16 is impaired, with the elimination of miR15 leading to increased BCL2 production. He pursues the resulting approaches for drug development and developed a microRNA gene chip for diagnosis.

He published over 680 scientific articles (2010). From 1990 to 1999 he was editor of Cancer Research .

In 1993, Croce received the Charles S. Mott Prize for Cancer Research. He is a member of the National Academy of Sciences (1996) and the Italian Academy of Sciences (2003). In 2003 he was awarded the President's Gold Medal for Public Health in Italy. In 2000 he received the Order of Merit of the Italian Republic and in 1999 the gold medal of the City of Paris. He is an honorary doctorate from Uppsala University . In 2006 he received the American Association for Cancer Research's Clowes Memorial Award for services to leukemia research and in 1994 the Pasarow Award (Robert J. and Claire Pasarow Foundation). He received the Richard and Hinda Rosenthal Award and the Pezcoller Award from the American Association for Cancer Research (AACR), the Henry M. Stratton Medal from the American Society of Hematology, the 2008 Szent Györgyi Prize for Cancer Research and the Léopold Griffuel Prize, and 2013 the InBev-Baillet Latour Health Prize . In 1994 he became an honorary member of the Japanese Cancer Research Society and is a Fellow of the American Academy of Arts and Sciences (2010) and the American Association for the Advancement of Science (2011). In 2018 he was awarded the Dan David Prize .

In 2017, the New York Times published an article accusing Croce of systematic violations of ethical science guidelines, including: a. the falsification of scientific data.

Web links

Individual evidence

  1. ↑ Date of birth according to American Men and Woman of Science , Thomson Gale 2005
  2. ↑ Croce, Klein Chromosome translocations and human cancer , Spektrum der Wissenschaft, May 1985
  3. ↑ Laudation for the Clowes Award, pdf  ( page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.@1@ 2Template: Dead Link / www.aacr.org  
  4. ↑ https://www.nytimes.com/2017/03/08/science/cancer-carlo-croce.html
personal data
SURNAME Croce, Carlo M.
ALTERNATIVE NAMES Croce, Carlo Maria
BRIEF DESCRIPTION American medical doctor and cancer researcher
DATE OF BIRTH December 17, 1944
PLACE OF BIRTH Milan