Caroline Kisker
Caroline Kisker (born May 1, 1964 in Berlin ) is a German biochemist and professor at the University of Würzburg . She heads the Rudolf Virchow Center for Experimental Biomedicine at the University of Würzburg together with Bernhard Nieswandt .
Life
Kisker studied biochemistry at the Free University of Berlin , where he received his doctorate in structural biology and biochemistry in 1994. She then moved to the USA and spent several years as a postdoc at the California Institute of Technology in Pasadena. In 1998 she moved to Stony Brook University as an assistant professor and was then associate professor there from 2011 to 2005.
In 2005 she became a professor at the Rudolf Virchow Center for Experimental Biomedicine at the University of Würzburg . She has been the dean of the Graduate School for Life Sciences since 2009 . From 2009 to 2016 she was the deputy head of the Rudolf Virchow Center for Experimental Biomedicine and since 2016 she has been managing the center together with Bernhard Nieswandt .
research
Kisker's research focuses on DNA repair mechanisms and the development of new antibiotics , especially against Mycobacterium tuberculosis , the causative agent of tuberculosis , and Staphylococcus aureus .
It deals with nucleotide excision repair (NER). This mechanism is important in the repair of DNA damage , for example after exposure to UV or chemotherapeutic agents. Kisker has analyzed the enzyme TFIIH-Helicase XPD , which is involved in the detection of DNA damage, and shown how mutations affect this protein. Mutations in the XPD enzyme lead, among other things, to moonlight disease ( Xeroderma pigmentosum ) and short stature ( Cockayne syndrome or trichothiodystrophy ).
Kisker also deals with the development of antibiotics using "structure based drug design". Your work has helped identify points of attack against tuberculosis. Among other things, she analyzed the structure of the enzyme FadA5 in the cholesterol metabolism of the mycobacterium tuberculosis, which plays an important role in chronic tuberculosis infections.
Awards
- Member of the Bavarian Academy of Sciences since 2017
- Since 2011 member ( matriculation number 7419 ) in the section Biochemistry and Biophysics of the National Academy of Sciences Leopoldina
- 2000 PEW fellow for biomedical research
- 1998–1999 Targeted Research Opportunity Award from the Stony Brook School of Medicine
- 1997–1998 Howard Hughes Postdoctoral Fellowship from the Howard Hughes Medical Institute
- 1995–1997 postdoctoral fellowship from the German Research Foundation
- 1995 Carl Ramsauer Prize
Web links
Individual evidence
- ↑ Member entry of Caroline Kisker (with picture) at the Bavarian Academy of Sciences , accessed on March 7, 2020.
- ↑ Member entry by Caroline Kisker (with picture and curriculum vitae) at the German Academy of Natural Scientists Leopoldina , accessed on March 7, 2020.
- ↑ Caroline F. Kisker, Ph.D. Retrieved March 7, 2020 .
| personal data | |
|---|---|
| SURNAME | Kisker, Caroline |
| BRIEF DESCRIPTION | German biochemist and university professor |
| DATE OF BIRTH | May 1, 1964 |
| PLACE OF BIRTH | Berlin |