Casein kinases

from Wikipedia, the free encyclopedia

Casein kinases are a group of enzymes from the group of protein kinases .

Representative

Casein kinases are serine / threonine protein kinases . They are divided into two subtypes, casein kinase I and casein kinase II . Type I casein kinases include the isoforms of casein kinases I alpha, beta 1, gamma 1, gamma 2, gamma 3, delta and epsilon. They are involved in the Wnt signaling pathway , the circadian rhythm , the regulation of the nuclear localization of transcription factors , DNA repair and transcription . Type II casein kinases are involved in the Wnt signaling pathway and include e.g. B. the casein kinase II alpha 1, alpha 2 and beta.

Casein kinase 1-alpha is the molecular target of lenalidomide , which leads to its ubiquitination and is therefore particularly effective in myelodysplastic syndrome with 5q deletion (del [5q]).

Individual evidence

  1. ↑ EJ Eide, DM Virshup: Casein kinase I: another cog in the circadian clockworks. In: Chronobiology international. Volume 18, Number 3, May 2001, pp. 389-398, PMID 11475410 .
  2. ^ Y. Gao, HY Wang: Casein kinase 2 Is activated and essential for Wnt / beta-catenin signaling. In: The Journal of biological chemistry. Volume 281, Number 27, July 2006, pp. 18394-18400, doi : 10.1074 / jbc.M601112200 , PMID 16672224 .
  3. ↑ Benjamin L. Ebert, Jan Krönke: Inhibition of Casein Kinase 1 Alpha in acute myeloid leukemia . New England Journal of Medicine 2018, Volume 279, Issue 19, Nov. 8, 2018, pages 1873–1874, [DOI: 10.1056 / NEJMcibr1811318]