Catherine Dulac

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Catherine Dulac 2011

Catherine G. Dulac (* 1963 ) is a French-American biologist who became known for her research in the molecular biological field of the olfactory sense in mammals , especially in relation to pheromones . She developed a novel screening method based on cDNA databases from individual neurons and a new method for cloning genes from individual neurons. As a postdoc , Dulac and Nobel Prize winner Richard Axel discovered the first family of mammalian pheromone receptors. Dulac is a Howard Hughes Medical Investigator at Harvard University .

biography

Dulac grew up in Montpellier and studied at the École normal supérieure ; In 1991 she received her PhD on a topic of developmental biology from the University of Paris. Her dissertation was entitled Étude de la différenciation des cellules gliales dans le système nerveux périphérique . She worked with Nicole Le Douarin on developmental mechanisms and did her postdoctoral studies with Richard Axel at Columbia University . There she identified the first genes that code for mammalian pheromone receptors.

Dulac moved to Harvard in 1996. In 2000 she was appointed associate professor and in 2001 full professor. She is currently a researcher at the Howard Hughes Medical Institute and was Chair of the Harvard Department of Molecular and Cellular Biology until 2013. She was followed by Alex Schier in 2014 .

research

Catherine Dulac's research focuses on two areas.

On the one hand, Dulac's group is attempting to understand the molecular, cellular and systemic logic of neural circuits in order to better classify their behavior during pheromone signaling. Questions are z. B. the nature of the pheromones and the receptors or the neural development of the connection between olfactory cells and the brain .

Dulac also works in the area of ​​genomic imprinting in the brain and epigenetic changes, on the one hand in the development of the brain and on the other hand in the brain of the adult individual. The results show that imprinting is an important factor in epigenetic change. Dulac uses molecular, genetic and electrophysiological methods.

Furthermore, Dulac researched in earlier work a new strategy for cloning cDNA , with which she was able to characterize a new family of pheromones in the vomeronasal organ . She also discovered molecules that are responsible for pheromone recognition and researched molecular strategies to interpret receptor signals in the vomeronasal organ.

Publications (selection)

  • Tali Kimchi, Jennings Xu, Catherine Dulac: A functional circuit underlying male sexual behavior in the female mouse brain . In: Nature . tape 448 , no. 7157 , 2007, p. 1009-1014 , doi : 10.1038 / nature06089 .
  • Ian Tietjen, Jason M. Rihel, Yanxiang Cao, Georgy Koentges, Lisa Zakhary, Catherine Dulac: Single-cell transcriptional analysis of neuronal progenitors . In: Neuron . tape 38 , no. 2 , April 24, 2003, ISSN  0896-6273 , p. 161-175 , PMID 12718852 .
  • E. Pantages, C. Dulac: A novel family of candidate pheromone receptors in mammals . In: Neuron . tape 28 , no. 3 , December 1, 2000, ISSN  0896-6273 , p. 835-845 , PMID 11163270 .
  • ER Liman, DP Corey, C. Dulac: TRP2: A candidate transduction channel for mammalian pheromone sensory signaling . In: Proceedings of the National Academy of Sciences . tape 96 , no. 10 , May 11, 1999, ISSN  0027-8424 , p. 5791-5796 , PMID 10318963 .
  • L. Belluscio, G. Koentges, R. Axel, C. Dulac: A map of pheromone receptor activation in the mammalian brain . In: Cell . tape 97 , no. 2 , April 16, 1999, ISSN  0092-8674 , p. 209-220 , PMID 10219242 .
  • Catherine Dulac, Richard Axel: A novel family of genes encoding putative pheromone receptors in mammals . In: Cell . tape 83 , no. 2 , October 20, 1995, ISSN  0092-8674 , p. 195-206 , PMID 7585937 .
  • Sex and the single splice . In: Cell . tape 121 , no. 5 , June 3, 2005, ISSN  0092-8674 , p. 664-666 , doi : 10.1016 / j.cell.2005.05.017 , PMID 15935752 .
  • with B. Grothe: Editorial: Sensory Systems. In: Current Opinion in Neurobiology. Volume 14, 2004, pp. 403-406.
  • with AT Torello: Molecular Detection of Pheromone Signals in Mammals: From Genes to Behavior. In: Nature Reviews Neuroscience. Volume 4, 2003, pp. 1-13.
  • The Physiology of Taste, Vintage 2000. In: Cell Volume 100, 2000, pp. 607-610.

Awards

literature

  • Making the paper: Catherine Dulac . In: Nature . tape 448 , no. 7157 , 2007, p. xiii-xiii , doi : 10.1038 / 7157xiiia .

Web links

Commons : Catherine Dulac  - collection of images, videos and audio files

Seminars:

Individual evidence

  1. ↑ Gitschier, J .: Vive La Différence: An Interview with Catherine Dulac . In: PLoS Genet. tape 7 , no. 6 , 2011, doi : 10.1371 / journal.pgen.1002140 , PMC 3121755 (free full text) - (English).
  2. ↑ a b Catherine Dulac. (No longer available online.) Harvard University, archived from the original June 15, 2011 ; accessed on June 14, 2016 . Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.mcb.harvard.edu
  3. ↑ a b c d e f Catherine Dulac. (PDF) academie-sciences.fr
  4. ↑ Harvard Portrait: Catherine Dulac In: Harvard Magazine. September 2005.
  5. ^ National Academy of Sciences
  6. ^ JW Hastings: Catherine Dulac Elected to Membership in the American Academy of Arts and Sciences. In: Harvard University MCB News. May 12, 2004.
  7. ^ Richard Lounsbery Award. In: nasonline.org. October 29, 2015, accessed May 22, 2016 .
  8. ↑ Catherine Dulac - List of the membres de l'Académie des sciences. Retrieved May 22, 2016 (French).
  9. ↑ Fellows of the AAAS: Catherine Dulac. (No longer available online.) American Association for the Advancement of Science, archived from the original on March 15, 2018 ; accessed on March 14, 2018 . Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.aaas.org
  10. ↑ Previous Recipients - UNC Neuroscience Center - UNC School of Medicine. In: med.unc.edu. October 23, 2014, accessed May 22, 2016 .
  11. ^ Neurosciences. (No longer available online.) In: fondation-ipsen.org. April 22, 2016, archived from the original on July 21, 2017 ; accessed on May 22, 2016 (English). Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.fondation-ipsen.org
  12. ↑ Catherine Dulac. In: nasonline.org. Retrieved May 22, 2016 .
  13. ^ Pradel Research Award. Retrieved May 22, 2016 .
personal data
SURNAME Dulac, Catherine
ALTERNATIVE NAMES Dulac, Catherine G.
BRIEF DESCRIPTION French-American biologist
DATE OF BIRTH 1963