Cholesteatosis
| Classification according to ICD-10 | |
|---|---|
| K82.4 | Cholesteatosis |
| ICD-10 online (WHO version 2019) | |
Under a Cholesteatose is meant a clinically harmless change in the gallbladder mucosa in the form of a net-like or stippchen- mucosa drawing in accumulation lipid-storing macrophages in folds of mucous membrane .
Synonyms
Terms used synonymously are cholesterosis , cholesterolosis , stipple gallbladder , strawberry gallbladder , fish scale gallbladder or lipoidosis of the gallbladder . The term lipoid cholecystitis is factually incorrect .
Epidemiology
The frequency in the unselected autopsy material is around 10 percent. The maximum age for women is around the age of 60 and for men around the age of 65. Overall, women are affected somewhat more frequently than men.
Pathophysiology
The disorder is apparently based on a pathologically increased absorption of lipids. This is promoted, among other things, by an increased cholesterol content in the bile , a build-up of bile within the gallbladder, and lymph drainage disorders in the area of the gallbladder wall. The lipids are presumably synthesized in the epithelia and released into the connective tissue below , where they are taken up by macrophages. Chemically , the stored material consists of cholesterol , cholesterol esters , free fatty acids and other lipids.
pathology
Depending on the degree of severity, either only small yellowish specks, a reticulate yellowish markings of the mucous membrane or small, yellowish, polypoid protrusions of the mucous membrane (so-called cholesterol polyps ) can be found in the area of the gallbladder mucosa . Similar changes are rarely observed in the area of the biliary or pancreatic duct . Histologically , the stroma of the mucous membrane located under the epithelium contains groups of lipid-storing macrophages (so-called foam cells or pseudoxanthoma cells ).
Therapy and prognosis
The change is asymptomatic, harmless and therefore does not require treatment.
