Christoph Plass

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Christoph Plass (born July 30, 1961 in Bremen ) is a German cancer researcher and human geneticist .

Life

Plass went to school in Emsdetten with the Abitur in 1980 and after completing his military service he studied biology at the Free University of Berlin from 1982 with a diploma in 1987. He received his doctorate in 1993 with Heinz Winking at the Medical University of Lübeck and was a post-doctoral student at the Institute of Physical and Physical Education Chemical Research at RIKEN in Tsukuba (Ibaraki) with Yoshihide Hayashizaki to learn the RLGS technique of gene analysis (simultaneous scanning of restriction enzyme attachments), and at the Roswell Park Cancer Institute in Buffalo (New York) with Verne Chapman. From 1996 he was a scientist at the Roswell Park Cancer Institute and from 1997 Assistant Professor at Ohio State University , where he was Associate Professor in 2002 and Professor in the Department of Human Tumor Genetics in 2005. In 2007 he became a professor at the German Cancer Research Center in Heidelberg (Department of Epigenomics and Cancer Risk Factors).

He researches the epigenetics of tumors, in particular changes in DNA methylation compared to normal processes and environmental influences on epigenetics. The focus is on leukemia and solid tumors in the lungs, neck and head area. He found evidence of tumor-specific, pattern-like changes in DNA methylation in malignant tumors. New target genes for tumor development and markers for diagnosis were identified.

In 2016 he received the Tsungming Tu Prize . In 2005 he became a Fellow of the American Association for the Advancement of Science . From 2002 to 2007 he was a Scholar of the Leukemia Lymphoma Society of America.

Fonts

  • CC Oakes, M. Seifert, Y. Assenov, L. Gu, M. Przekopowitz, AS Ruppert, Q. Wang, A. Serva, S. Koser, D. Brocks, D. Lipka, O. Bogatyrova, D. Mertens, M. Zapatka, P. Lichter, H. Döhner, R. Küppers, T. Zenz, S. Stilgenbauer, JC Byrd, C. Plass: Progressive epigenetic programming during B cell maturation yields a continuum of disease phenotypes in chronic lymphocytic leukemia. In: Nat Genet. 48 (3), 2016, pp. 253-264, doi: 10.1038 / ng.3488 .
  • Q. Wang, L. Gu, A. Adey, B. Radlwimmer, W. Wang, V. Hovestadt, M. Bähr, S. Wolf, J. Shendure, R. Eils, C. Plass, D. Weichenhan: Tagmentation- based whole-genome bisulfite sequencing. In: Nat Protoc. 8, 2013, pp. 2022-2032, doi: 10.1038 / nprot.2013.118 .
  • K. Arab, YJ Park, AM Lindroth, A. Schäfer, C. Oakes, D. Weichenhan, A. Lukanova, E. Lundin, A. Risch, M. Meister, H. Dienemann, G. Dyckhoff, C. Herold- Mende, I. Grummt, C. Niehrs, C. Plass: Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A. In: Mol Cell. 55, 2014, pp. 604-614, doi: 10.1016 / j.molcel.2014.06.031 .
  • C. Weigel, MR Veldwijk, CC Oakes, P. Seibold, A. Slynko, DB Liesenfeld, M. Rabionet, SA Hanke, F. Wenz, E. Sperk, A. Benner, C. Rösli, R. Sandhoff, Y. Assenov, C. Plass, C. Herskind, J. Chang-Claude, P. Schmezer, O. Popanda: Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis. In: Nat Commun. 7, 2016, p. 10893, doi: 10.1038 / ncomms10893 .

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personal data
SURNAME Plass, Christoph
BRIEF DESCRIPTION German human geneticist and cancer researcher
DATE OF BIRTH July 30, 1961
PLACE OF BIRTH Bremen