Colipase
| Colipase | ||
|---|---|---|
|
||
| Mass / length primary structure | 11.9 kilodaltons / 112 amino acids | |
| Identifier | ||
| Gene name (s) | CLPS | |
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 1208 | 109791 |
| Ensemble | ENSG00000137392 | ENSMUSG00000024225 |
| UniProt | P04118 | Q9CQC2 |
| Refseq (mRNA) | NM_001252597 | NM_025469 |
| Refseq (protein) | NP_001239526 | NP_079745 |
| Gene locus | Chr 6: 35.79 - 35.8 Mb | Chr 17: 28.56 - 28.56 Mb |
| PubMed search | 1208 |
109791
|
The colipase is approximately 12 k Da large protein , which as a cofactor for the function of pancreatic lipase is necessary. It is formed as an inactive precursor ( procolipase ) in the pancreas , which is cleaved in the small intestine by trypsin into colipase and the N-terminal pentapeptide enterostatin .
The colipase forms the prolipase-pancreatic lipase complex with the pancreatic lipase and mediates the contact of the lipase with the lipid interfaces consisting of phospholipids or bile acids . In addition, the colipase causes a conformational change in the lipase, which opens the lid over the active center of the lipase.
literature
- Walter F. Boron, Emile L. Boulpaep: Medical Physiology . 2nd edition, Elsevier Health Sciences, 2012, ISBN 9781455711819 , p. 963.
- Peter C. Heinrich et al .: Human biochemistry: With molecular biology and pathobiochemistry . Springer, 2014, ISBN 9783642179723 , p. 761.