David Cushman
David W. Cushman (born November 15, 1939 - † August 14, 2000 ) was an American biochemist . With Miguel Ondetti Captopril he developed the first ACE inhibitor . This was also one of the first examples of rational drug design .
Cushman received his PhD in biochemistry from Irwin C. Gunsalus in 1966 on the subject of Methylene Hydroxylase Monooxygenases: Components and Properties of 2-Bornanone 5-Exo-Hydroxylase at the University of Illinois at Urbana-Champaign and then from 1968 at the Squibb Research Institute (Squibb Institute of Medical Research). In 1974 he developed captopril there with Ondetti. It was approved by the FDA in 1981.
In 1992 he and Miguel Ondetti received the American Chemical Society's ACS Award for Creative Invention . In 2007, Cushman was inducted into the National Inventors Hall of Fame . In 1999 he and Ondetti received the Lasker ~ DeBakey Clinical Medical Research Award and in 1982 both received the GlaxoSmithKline Alfred Burger Award. In 1991, Cushman was awarded the Warren Alpert Foundation Prize .
Fonts
- with B. Rubin, M. Ondetti: Design of specific inhibitors of angiotensin-converting enzymes: new class of orally active antihypertensive agents, Science, Volume 196, 1977, pp. 441-444.
Web links
Individual evidence
- ↑ biographical data, publications and Academic pedigree of David W. Cushman at academictree.org, accessed on 28 January 2018th
- ^ ACS Medicinal Chemistry Hall of Fame
| personal data | |
|---|---|
| SURNAME | Cushman, David |
| ALTERNATIVE NAMES | Cushman, David W. |
| BRIEF DESCRIPTION | American chemist |
| DATE OF BIRTH | November 15, 1939 |
| DATE OF DEATH | August 14, 2000 |