Demelverin

Structural formula
General
Non-proprietary name	Demelverin
other names	Metphenethamine; N -methyldiphenethylamine; N -Methyl-2-phenyl- N - (2-phenylethyl) ethanamine ( IUPAC );
Molecular formula	C 17 H 21 N
External identifiers / databases
EC number	630-792-9
ECHA InfoCard	100.159.090
PubChem	65608
Wikidata	Q1185280
Drug information
Drug class	Antispasmodic
properties
Molar mass	239.36 g · mol -1
safety instructions
GHS labeling of hazardous substances Caution
H and P phrases	H: 315-319-335
	P: ?
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Demelverine is a drug that is used as an antispasmodic . It shows an effect similar to papaverine . In combination with the anticholinergic Trihexyphenidyl , it was previously marketed under the trade name Spasman ^® .

The active ingredient Demelverin was developed by Fahlberg-List in Magdeburg in the 1950s and used until the reunification in the GDR . It was later taken over by Merckle.

application areas

It was used for spastic stomach or intestinal complaints (e.g. irritable bowel syndrome , irritable stomach ), biliary or renal colic and dysmenorrhea . Its application is viewed rather critically nowadays.

Individual evidence

↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of N-methyldiphenethylamine in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), which was accessed on January 15, 2020, is reproduced from a self-classification by the distributor .
↑ ^a ^b R. Arendt: "Spasman: Rediscovered Spasmolytic". Deutsches Ärzteblatt 94 (1997). Pp. 51-52 ( online ).
^ Stiftung Warentest : Spasman solution . 2004. Stiftung Warentest: SPASMAN Scop. Ampullen test.de, December 1, 2012.

[1] Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of N-methyldiphenethylamine in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), which was accessed on January 15, 2020, is reproduced from a self-classification by the distributor .

[q1-2] R. Arendt: "Spasman: Rediscovered Spasmolytic". Deutsches Ärzteblatt 94 (1997). Pp. 51-52 ( online ).

[3] Stiftung Warentest : Spasman solution . 2004. Stiftung Warentest: SPASMAN Scop. Ampullen test.de, December 1, 2012.