Dennis Lo

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Yuk-ming Dennis Lo , quoted by YMD Lo, ( Chinese  盧煜明  /  卢煜明 , Pinyin Lú Yùmíng , IPA ( standard Chinese) [ lǔ ŷmǐŋ ], Jyutping Lou 4 Juk 1 ming 4 ; * October 12, 1963 in Hong Kong ) is a Chinese laboratory doctor , known for the non-invasive prenatal diagnosis of fetuses via their DNA in the mother's blood plasma.

Live and act

Dennis Lo graduated from the University of Cambridge with a bachelor's degree and an MD and Ph. D. from the University of Oxford . He was then Lecturer in Clinical Biochemistry at Radcliffe Hospital, Oxford Medical School's Teaching Hospital, and a Fellow of Green College , Oxford. In 1997 he returned to Hong Kong. He is Li Kai Shing Professor of Medicine and Professor of Chemical Pathology at the Chinese University of Hong Kong and Director of the Li Ka Shing Institute of Health Science .

In 1997 he discovered the presence of fetal DNA in the bloodstream of expectant mothers and the possibility of prenatal diagnosis from it. Later he and his team discovered the existence of cell-free fetal RNA in the mother's blood plasma and they showed that it can be used for the diagnosis of Down's syndrome (trisomy 21). They developed methods with polymerase chain reaction and massively parallel DNA sequencing from the fragments of the genetic material of the fetus in the maternal blood plasma to analyze the genetic material of the fetus and recognized the importance of epigenetic markers for prenatal diagnostics.

Since 2016 Thomson Reuters has counted him among the favorites for a Nobel Prize ( Thomson Reuters Citation Laureates ) due to the number of his citations .

Fonts

  • with NM Hjelm, C. Fidler, IL Sargent, MFMurphy, PF Chamberlain, PM Poon, CW Redman, JS Wainscoat Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma , New England Journal of Medicine, Volume 339, 1998, p. 1734-1738.
  • with N. Corbetta, PF Chamberlain, V. Rai, IL Sargent, CW Redman, JS Wainscoat Presence of fetal DNA in maternal plasma and serum , The Lancet, Volume 350, 1997, pp. 485-487.
  • with RWK Chiu: Prenatal diagnosis: progress through plasma nucleic acids , Nature Review Genetics, Volume 8, 2007, pp. 71-77
  • with EKO Ng, NBY Tsui, TK Lau, TN Leung, RWK Chiu, NS Panesar, LCW Lit, KW Chan mRNA of placental origin is readily detectable in maternal plasma , Proceedings National Academy USA, Volume 100, 2003, pp. 4748-4753 .
  • with KC Allen Chan, Chunming Ding, Ageliki Gerovassili, Sze W. Yeung, Rossa WK Chiu, Tse N, Leung, Tze K. Lau, Stephen SC Chim, Grace TY Chung, Kypros H. Nicolaides Hypermethylated RASSFIA in Maternal Plasma: A Universal Fetal DNA Marker that Improves the Reliability of Noninvasive Prenatal Diagnosis , Clin. Chem., Vol. 52, 2006, pp. 2211-2218.

Awards (selection)

  • 2005 State Natural Science Award (China)
  • 2006 Abbott Award from the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)
  • 2006 Distinguished Science Award from the US National Academy of Clinical Biochemistry
  • 2007 Sigi Zeiring Award from the American Association of Clinical Chemistry
  • 2009 Fulbright Distinguished Scholar
  • 2011 member of the Royal Society
  • 2013 member of the National Academy of Sciences
  • 2014 King Faisal Prize

Individual evidence

  1. ↑ Web of Science Predicts 2016 Nobel Prize Winners. (No longer available online.) In: ipscience.thomsonreuters.com. September 21, 2016, archived from the original on September 21, 2016 ; accessed on September 21, 2016 (English). Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / ipscience.thomsonreuters.com
  2. ↑ To receive the AACC award
  3. ^ New Fellows 2011 at the Royal Society (royalsociety.org); Retrieved January 17, 2014
  4. ^ Yuk-Ming Dennis Lo at the National Academy of Sciences (nasonline.org); Retrieved January 17, 2014
  5. ^ CUHK Professor Dennis Lo Awarded King Faisal International Prize for Medicine at the Chinese University of Hong Kong (cuhk.edu.hk); Retrieved January 17, 2014

Web links

personal data
SURNAME Lo, Dennis
ALTERNATIVE NAMES Lo, Yuk Ming Dennis; Lo, Yuk-Ming Dennis; Lo, YM Dennis; 盧煜明
BRIEF DESCRIPTION British-Chinese laboratory physician
DATE OF BIRTH October 12, 1963
PLACE OF BIRTH Hong Kong