The f 1
| Peptidase 1 | ||
|---|---|---|
|
||
| according to PDB 3D6S , in three views | ||
| other names |
Allergen der f I, major mite fecal allergen der f 1 |
|
| Mass / length primary structure | 321 amino acids , 36,435 Da ( zymogen ), 223 aa in the active form | |
| Identifier | ||
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.4.22.65 | |
The Dermatophagoides farinae peptidase 1 (Der f 1) is an enzyme from the group of cysteine proteases and is produced by the American house dust mite Dermatophagoides farinae . It is one of the major house dust allergens of the people , as well as its homologues Der p 1 from the European house dust mite Dermatophagoides pteronyssinus and Eur m 1 out of Mayne-dust mite Euroglyphus maynei .
properties
As a cysteine protease, p 1 has the amino acid cysteine in its active center . It is an endopeptidase and preferentially hydrolyzes peptides with a hydrophobic or basic amino acid at position P2. The release occurs fecally .
Web links
Individual evidence
- ↑ JC Bessot, G. Pauli: Mite allergens: an overview. In: European annals of allergy and clinical immunology. Volume 43, Number 5, October 2011, pp. 141-156, PMID 22145250 .