The p 1

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Peptidase 1
Peptidase 1
according to PDB  3F5V , in two views
other names

Allergen Der p I, Major mite fecal allergen Der p 1, Allergen: Der p 1

Existing structure data : PDB  1XKG , PDB  2AS8 , PDB  3RVW

Mass / length primary structure 320 amino acids , 36,104 Da ( zymogen ), 222 amino acids, 25 KDa
Identifier
External IDs
Enzyme classification
EC, category 3.4.22.65

The Dermatophagoides pteronyssinus peptidase 1 (Der p 1) is an enzyme from the group of cysteine ​​proteases and is produced by the European house dust mite Dermatophagoides pteronyssinus . It is one of the major house dust allergens of the people , as well as its homologues Der f 1 from the American house dust mite Dermatophagoides farinae and Eur m 1 out of Mayne-dust mite Euroglyphus maynei .

properties

As a cysteine ​​protease, p 1 has the amino acid cysteine in its active center . It is an endopeptidase and preferentially hydrolyzes peptides with a hydrophobic or basic amino acid at position P2. The p 1 is glycosylated . The p 1 is formed in the digestive tract, the release of Der p 1 occurs in the feces . In house dust allergy sufferers, antibodies of the immunoglobulin E type are formed against, among others, Der p 1 and Der p 2 , which are used for diagnosis . Over 40% of those allergic to house dust with a proven reaction to extracts of Dermatophagoides pteronyssinus have IgE against Der p 1. The p 1 is involved in the development of atopic dermatitis .

history

The p 1 was the first house dust allergen to be described in 1980 by Martin D. Chapman and Thomas Platts-Mills. In the following years it was identified as a cysteine ​​protease, with enzyme activity similar to that of actinidin and papain . In the 1990s, the allergenic activity was attributed to the protease activity.

See also

The p 2

Web links

Individual evidence

  1. ↑ JC Bessot, G. Pauli: Mite allergens: an overview. In: European annals of allergy and clinical immunology. Volume 43, Number 5, October 2011, pp. 141-156, PMID 22145250 .
  2. ↑ B. Thomas, P. Heap, F. Carswell: Ultrastructural localization of the allergen Der p I in the gut of the house dust mite Dermatophagoides pteronyssinus. In: International archives of allergy and applied immunology. Volume 94, Numbers 1-4, 1991, pp. 365-367, PMID 1937901 .
  3. ↑ X. Yang, G. Fan, J. Li: Diagnostic value of Der p 1 and Der p 2 specific IgE in Dermatophagoides pteronyssinus IgE sensitization. In: Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology. Volume 116, Number 4, April 2016, pp. 295-301, doi: 10.1016 / j.anai.2016.02.010 , PMID 27055990 .
  4. ↑ D. Posa, S. Perna, Y. Resch, C. Lupinek, V. Panetta, S. Hofmaier, A. Rohrbach, L. Hatzler, L. Grabenhenrich, O. Tsilochristou, KW Chen, CP Bauer, U. Hoffman , J. Forster, F. Zepp, A. Schuster, U. Wahn, T. Keil, S. Lau, S. Vrtala, R. Valenta, PM Matricardi: Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life. In: The Journal of allergy and clinical immunology. [Electronic publication before printing] October 2016, doi: 10.1016 / j.jaci.2016.08.014 , PMID 27793411 .
  5. ↑ N. Fuiano, C. Incorvaia: Dissecting the causes of atopic dermatitis in children: less foods, more mites. In: Allergology international: official journal of the Japanese Society of Allergology. Volume 61, number 2, June 2012, pp. 231-243, doi: 10.2332 / allergolint.11-RA-0371 , PMID 22361514 .
  6. ↑ AJ Lee, J. Machell, AH Van Den Broek, AJ Nisbet, HR Miller, RE Isaac, JF Huntley: Identification of an antigen from the sheep scab mite, Psoroptes ovis, homologous with house dust mite group I allergens. In: Parasite immunology. Volume 24, Number 8, August 2002, pp. 413-422, PMID 12406195 .
  7. ↑ MD Chapman, TA Platts-Mills: Purification and characterization of the major allergen from Dermatophagoides pteronyssinus-antigen P1. . In: Journal of Immunology . 125, No. 2, August 1980, pp. 587-92. PMID 6771329 .
  8. ^ A b Martin D. Chapman, Sabina Wuenschmann, Anna Pomes: Proteases as Th2 adjuvants . In: Current Allergy and Asthma Reports . 7, No. 5, September 2007, pp. 363-367. doi : 10.1007 / s11882-007-0055-6 . PMID 17697645 .